Results 31 to 40 of about 41,598 (256)
Dysfunctional mitochondrial fission impairs cell reprogramming [PDF]
Cell Cycle, 2016 We have recently shown that mitochondrial fission is induced early in reprogramming in a Drp1-dependent manner; however, the identity of the factors controlling Drp1 recruitment to mitochondria was unexplored. To investigate this, we used a panel of RNAi targeting factors involved in the regulation of mitochondrial dynamics and we observed that MiD51 ...
Prieto, J +10 more
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Mechanisms of Mitochondrial Fission and Fusion [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Mitochondria continually change shape through the combined actions of fission, fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and the degree to which they form closed networks are determined by the balance between fission and fusion rates. These rates are influenced by metabolic and pathogenic conditions inside mitochondria
Alexander M, van der Bliek +2 more
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Neurobiology of Disease, 2011 Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold +3 more
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The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. [PDF]
PLoS ONE, 2012 Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1.
Qian Guo +4 more
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Mitochondrial fission/fusion and cardiomyopathy [PDF]
Current Opinion in Genetics & Development, 2016 Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
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Acta Pharmaceutica Sinica B, 2017 Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of ...
Jing Jin +10 more
doaj +1 more source
Mechanical force induces mitochondrial fission
eLife, 2017 Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion.
Helle, S +12 more
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Participation of mitochondrial fission during mitophagy [PDF]
Cell Cycle, 2013 Due to the key role of mitochondria in cell metabolism, the quantity and quality of this organelle must be maintained properly, which is achieved by constitutive mitochondrial fusion and fission as well as biogenesis and degradation. A fission complex controls mitochondrial division, whereas degradation occurs primarily through autophagy.
Mao, Kai, Klionsky, Daniel J
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An Ancient Fission of Mitochondrial cox1 [PDF]
Molecular Biology and Evolution, 2009 Many genes inherited from the alpha-proteobacterial ancestor of mitochondria have undergone evolutionary transfer to the nuclear genome in eukaryotes. In some rare cases, genes have been functionally transferred in pieces, resulting in split proteins that presumably interact in trans within mitochondria, fulfilling the same role as the ancestral ...
Ryan M R, Gawryluk, Michael W, Gray
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PLoS Biology, 2023 Mitochondria are in a constant balance of fusion and fission. Excessive fission or deficient fusion leads to mitochondrial fragmentation, causing mitochondrial dysfunction and physiological disorders.
Jiajia He +17 more
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