Results 51 to 60 of about 41,598 (256)
Frontiers in Pharmacology, 2021 Mitochondrial dysfunction is involved in the pathogenesis of Parkinson’s disease (PD). Mitochondrial morphology is dynamic and precisely regulated by mitochondrial fission and fusion machinery.
Hanyu Yang +11 more
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Mechano-induced mitochondrial fission [PDF]
Science, 2017 Cell Biology The inside of a cell is crowded with lots of different organelles that need to be accommodated in a constrained environment. What happens when different organelles bump into one another? Dynamic reticular organelles, such as the endoplasmic reticulum and mitochondria, are continually being remodeled.
openaire +1 more source
Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission [PDF]
Current Biology, 2004 Mitochondrial fission requires the evolutionarily conserved dynamin related protein (DRP1), which is recruited from the cytosol to the mitochondrial outer membrane to coordinate membrane scission. Currently, the mechanism of recruitment and assembly of DRP1 on the mitochondria is unclear.
Harder, Zdena +2 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Neurobiology of Disease, 2009 Mutations in the GDAP1 gene lead to recessively or dominantly inherited peripheral neuropathies (Charcot–Marie–Tooth disease; CMT). Here, we demonstrate that GDAP1 is a mitochondrial fission factor whose activity is dependent on the fission factors Drp1 ...
Axel Niemann +3 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 Melatonin is an indoleamine produced in the pineal gland and has many physiological roles. There is increasing evidence that melatonin ameliorates cadmium (Cd)-induced nephrotoxicity.
Wenxuan Dong +11 more
doaj +1 more source
Intraspecific diversity of fission yeast mitochondrial genomes [PDF]
Genome Biology and Evolution, 2019 ABSTRACTThe fission yeastSchizosaccharomyces pombeis an important model organism, but its natural diversity and evolutionary history remain under-studied. In particular, the population genomics of theS. pombemitochondrial genome (mitogenome) has not been thoroughly investigated.
Yu-Tian Tao +6 more
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Mitochondrial Fission: Rings around the Organelle [PDF]
Current Biology, 2013 Mitochondria form a dynamic network in which organelles fuse or divide in response to metabolic changes or cellular stress. New work shows that mitochondria do not divide in isolation from other cellular structures. Rather, they carry out this process in partnership with the endoplasmic reticulum and actin filaments.
openaire +2 more sources
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source