Results 251 to 260 of about 57,770 (292)

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3054-3069, April 2026.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

Targeting the mitochondrial metabolite-dynamics-MDVs-MitoEVs axis: a new frontier in osteoarthritis management. [PDF]

J Transl Med
Zhang T, Zhang H, Chen X, Liu Y, Han X, Zhu W, Liu Y, Zeng G, Jiao K.   +8 more
europepmc   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications. [PDF]

Mediators Inflamm
Liao X, Wang Y, Zhang Z, Qu X, Zhou G.
europepmc   +1 more source

Mitochondrial homeostasis meets novel programmed cell death: crosstalk mechanisms underlying cardiovascular diseases progression. [PDF]

Cell Commun Signal
Li M, Zhang Y, Hu Y, Qin Y, Zheng Y, Lv S, Zhang J.   +6 more
europepmc   +1 more source

Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications. [PDF]

Front Mol Biosci
Psvv C, Sunil S, Thuyyath N, Kokkanti RR, Lavudi K.   +4 more
europepmc   +1 more source

Metformin Attenuates Osteoarthritis Progression by Modulating Mitochondrial Dynamics via Activation of the AMPK/Drp1 Pathway. [PDF]

J Inflamm Res
Yang Y, Zhou H, Yang J, Li F, Hu Q, Jia Y, Huang W, Qin L, Zhou Y.   +8 more
europepmc   +1 more source

Drp1-FGF21 axis drives FAPs-mediated fibro-adipogenic degeneration in Duchenne muscular dystrophy

De Palma C, Casati S, Zecchini S, Gentil C, Gjana O, Lociuro L, Caccia M, Lavagnino Z, Schorn T, Bottan D, Ogno P, Mbissam HD, Mocciaro E, Parazzoli D, Cervia D, Clementi E, Pietri-Rouxel F, Perrotta C, Giovarelli M, FALCONE S.   +19 more
europepmc   +1 more source