Results 51 to 60 of about 253,295 (285)

Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy [PDF]

, 2015
Defects in mitochondrial fusion or fission are associated with many pathologies, raising the hope that pharmacological manipulation of mitochondrial dynamics may have therapeutic benefit.
Agah, Alexander, Brand, Cassidy-Stone, Chen, Chen, Chen, Chen, Chen, Clary Clish, David C. Chan, Delettre, Dorn, Friedman, Gandre-Babbe, Harvey, Hayashi, Hsiuchen Chen, Ikeda, Ishihara, J. Michael McCaffery, Kageyama, Kasahara, Lopaschuk, Losón, Mishra, Mohit Jain, Otera, Papanicolaou, Postic, Qi, Sadate-Ngatchou, Shamseldin, Shuxun Ren, Song, Vamsi Mootha, Wakabayashi, Waterham, Züchner   +38 more
core   +4 more sources

Bok regulates mitochondrial fusion and morphology [PDF]

Cell Death & Differentiation, 2019
Bok (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway, but the cellular role that Bok plays is controversial. Remarkably, endogenous Bok is constitutively bound to inositol 1,4,5-trisphosphate receptors (IP3Rs) and is stabilized by this interaction. Here we report that despite the strong
Jacqualyn J. Schulman, Laura M. Szczesniak, Eric N. Bunker, Heather A. Nelson, Michael W. Roe, Larry E. Wagner, David I. Yule, Richard J. H. Wojcikiewicz   +7 more
openaire   +2 more sources

Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity [PDF]

Jichu yixue yu linchuang
Adriamycin is a widely used anti-tumor drug. Targeting mitochondrial fusion proteins/mitofusion 1/2(MFN1/2) and nuclear factor-erythroid 2-related factor 2(NRF2) can up-regulate the expression of mitochondrial fusion protein through PKCε/Stat3/MFN2 ...
WANG Yuqi, WANG Xinyu, LUO Haowen, LU Zhaoxin, ZHAO Yiwei, CHANG Pan
doaj   +1 more source

Mitochondrial fission/fusion and cardiomyopathy [PDF]

Current Opinion in Genetics & Development, 2016
Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
openaire   +2 more sources

Mitochondrial Fusion Machinery Specifically Involved in Energy Deprivation-Induced Autophagy

Frontiers in Cell and Developmental Biology, 2020
Mitochondria are highly dynamic organelles, which can form a network in cells through fusion, fission, and tubulation. Its morphology is closely related to the function of mitochondria. The damaged mitochondria can be removed by mitophagy.
Choufei Wu, Weijing Yao, Wenwen Kai, Weikang Liu, Wenlve Wang, Shuzhen Li, Yingcong Chen, Xiaoyong Wu, Liefeng Wang, Ying Li, Jingjing Tong, Jing Qian, Liqin Zhang, Zhi Hong, Zhi Hong, Cong Yi   +15 more
doaj   +1 more source

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

World Journal of Surgical Oncology, 2022
Background Mitochondria play critical roles in cellular physiological activity as cellular organelles. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands. Mitochondrial dynamics, which are
Jixiang Xing, Luyao Qi, Xiaofei Liu, Guangxi Shi, Xiaohui Sun, Yi Yang   +5 more
doaj   +1 more source

Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition

Ecotoxicology and Environmental Safety, 2023
Triphenyl phosphate (TPHP) is a widely used organophosphate flame retardant and has biological toxicity. Previous studies showed TPHP can restrain testosterone biosynthesis in Leydig cells, while the underlying mechanisms remain unclear.
Minxin Wang, Jinyu Xu, Zhengbo Zhao, Lichao Gong, Yu Su, Zhichao Fang, Pengfei Chen, Yifan Liu, Lianshuang Zhang, Feibo Xu   +9 more
doaj   +1 more source

Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION. [PDF]

, 2016
The relevance of mitochondrial phosphate carrier (PiC), encoded by SLC25A3, in bioenergetics is well accepted. However, little is known about the mechanisms mediating the cellular impairments induced by pathological SLC25A3 variants.
Acoba, Michelle G., Anderson-Pullinger, Lauren, Claypool, Steven M., Golenár, Tünde, Gál, Aniko, Hajnóczky, György, Li, Qipei, Moffat, Cynthia, Seifert, Erin L., Sondheimer, Neal   +9 more
core   +2 more sources

Mitochondrial division, fusion and degradation

The Journal of Biochemistry, 2019
Abstract The mitochondrion is an essential organelle for a wide range of cellular processes, including energy production, metabolism, signal transduction and cell death. To execute these functions, mitochondria regulate their size, number, morphology and distribution in cells via mitochondrial division and fusion.
Daisuke, Murata, Kenta, Arai, Miho, Iijima, Hiromi, Sesaki   +3 more
openaire   +3 more sources

Mechanisms of Mitochondrial Fission and Fusion [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Mitochondria continually change shape through the combined actions of fission, fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and the degree to which they form closed networks are determined by the balance between fission and fusion rates. These rates are influenced by metabolic and pathogenic conditions inside mitochondria
Alexander M, van der Bliek, Qinfang, Shen, Sumihiro, Kawajiri   +2 more
openaire   +2 more sources