Results 41 to 50 of about 29,418 (143)

Characterisation of cold-induced mitochondrial fission in porcine aortic endothelial cells

Molecular Medicine, 2022
Background Previously, we observed that hypothermia, widely used for organ preservation, elicits mitochondrial fission in different cell types. However, temperature dependence, mechanisms and consequences of this cold-induced mitochondrial fission are ...
Leonard Quiring, Björn Walter, Niklas Lohaus, Dhanusha Schwan, Anja Rech, Andrea Dlugos, Ursula Rauen   +6 more
doaj   +1 more source

All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission

Cells, 2021
In the heart, mitochondrial homeostasis is critical for sustaining normal function and optimal responses to metabolic and environmental stressors.
Bojjibabu Chidipi, Syed Islamuddin Shah, Michelle Reiser, Manasa Kanithi, Amanda Garces, Byeong J. Cha, Ghanim Ullah, Sami F. Noujaim   +7 more
doaj   +1 more source

Mitochondria- and ER-associated actin are required for mitochondrial fusion

Nature Communications
Mitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove ...
Priya Gatti, Cara Schiavon, Julien Cicero, Uri Manor, Marc Germain   +4 more
doaj   +1 more source

Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. [PDF]

PLoS ONE, 2017
The majority of transplanted kidneys are procured from deceased donors which all require exposure to cold storage (CS) for successful transplantation.
Nirmala Parajuli, Stephen Shrum, Julia Tobacyk, Alex Harb, John M Arthur, Lee Ann MacMillan-Crow   +5 more
doaj   +1 more source

Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics [PDF]

The EMBO Journal, 2009
Visualizing mitochondrial fusion in real time, we identified two classes of fusion events in mammalian cells. In addition to complete fusion, we observed transient fusion events, wherein two mitochondria came into close apposition, exchanged soluble inter-membrane space and matrix proteins, and re-separated, preserving the original morphology ...
Xingguo, Liu, David, Weaver, Orian, Shirihai, György, Hajnóczky   +3 more
openaire   +2 more sources

Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. [PDF]

PLoS ONE, 2012
Mitochondria are highly-dynamic organelles, but it is challenging to monitor quantitatively their dynamics in a living cell. Here we developed a novel approach to determine the global occurrence of mitochondrial fission and fusion events in living human ...
Shiqi Wang, Weiming Xiao, Sicong Shan, Chunsun Jiang, Ming Chen, Yan Zhang, Shouqin Lü, Juan Chen, Chuanmao Zhang, Quan Chen, Mian Long   +10 more
doaj   +1 more source

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases [PDF]

Human Molecular Genetics, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial dysfunction often have a neurodegenerative component.
Chen, Hsiuchen, Chan, David C.
openaire   +3 more sources

The effects of different exercise training protocols on mitochondrial dynamics in skeletal and cardiac muscles of Wistar rats

Journal of Orthopaedic Surgery and Research
Background Mitochondrial fission and fusion both contribute to maintaining mitochondrial function and optimizing bioenergetic capacity. Objective The aim of this study was to compare the effect of aerobic and resistance training on mitochondrial fission ...
Amir Hossein Haghighi, Mohammad Reza Bandali, Roya Askari, Hadi Shahrabadi, Rosario Barone, Roberto Bei, Pasquale Farsetti, Marco Alfonso Perrone   +7 more
doaj   +1 more source

Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets

Cell Communication and Signaling
Colorectal cancer (CRC) is a significant public health concern, and its development is associated with mitochondrial dysfunction. Mitochondria can adapt to the high metabolic demands of cancer cells owing to their plasticity and dynamic nature.
Zihong Wu, Chong Xiao, Jing Long, Wenbo Huang, Fengming You, Xueke Li   +5 more
doaj   +1 more source

Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease

Neurobiology of Disease, 2013
Nascent evidence indicates that mitochondrial fission, fusion, and transport are subject to intricate regulatory mechanisms that intersect with both well-characterized and emerging signaling pathways.
Theodore J. Wilson, Andrew M. Slupe, Stefan Strack   +2 more
doaj   +1 more source