Results 51 to 60 of about 29,418 (143)

Control of Mitochondrial Function by Fusion and Fission [PDF]

Biophysical Journal, 2017
Several neurodegenerative diseases are associated with defects in mitochondrial fusion or fission, which are opposing processes that regulate mitochondrial function. This observation raises the issue of whether a defect in one process can be alleviated by simultaneously reducing the opposing process. We used mouse models to address this issue. Mff is a
Chen, Hsiuchen, Chan, David
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Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells

Veterinary Sciences
Background: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection.
Xiuhan Xu, Yuan Zhao, Zhenbang Zhu, Wei Wen, Xiangdong Li   +4 more
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Bioenergetic role of mitochondrial fusion and fission

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Mitochondria are highly dynamic organelles. Frequent cycles of fusion and fission adapt the morphology of the mitochondrial compartment to the metabolic needs of the cell. Mitochondrial fusion is particularly important in respiratory active cells. It allows the spreading of metabolites, enzymes, and mitochondrial gene products throughout the entire ...
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Role of mitochondrial lipids in guiding fission and fusion [PDF]

Journal of Molecular Medicine, 2014
Clinically important links have been established between mitochondrial function and cardiac physiology and disease in the context of signaling mechanisms, energy production, and muscle cell development. The proteins and processes that drive mitochondrial fusion and fission are now known to have emergent functions in intracellular calcium homeostasis ...
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Modulation of Mitochondrial Dynamics in Primary Hippocampal Cultures of 5xFAD Mice by Mdivi-1, MFP, and Exogenous Zinc

Frontiers in Bioscience-Landmark
Background: Mitochondrial dynamics—the balance between fission, fusion, and mitophagy—are essential for maintaining cellular homeostasis and are increasingly implicated in the pathogenesis of Alzheimer’s disease (AD).
Alina Chaplygina, Daria Zhdanova
doaj   +1 more source

Principles of mitochondrial fusion and fission cycle in neurons [PDF]

SpringerPlus, 2015
Mitochondrial fusion-fission dynamics play a crucial role in many important cell processes. These dynamics control mitochondrial morphology, which in turn influences several important mitochondrial properties including mitochondrial bioenergetics and quality control, and they appear to be affected in several neurodegenerative diseases.
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Mitochondrial Fusion, Fission, and Biogenesis in Prolonged Critically Ill Patients [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2012
Critical illness induces swelling, enlargement, and dysfunction of mitochondria, which in liver, but not in muscle, is aggravated by excessive hyperglycemia. We previously demonstrated impaired autophagic clearance of damaged mitochondria in fed prolonged critically ill patients. Impaired fusion/fission-mediated repair and/or renewal through biogenesis
Ilse, Vanhorebeek, Jan, Gunst, Sarah, Derde, Inge, Derese, Magaly, Boussemaere, André, D'Hoore, Pieter J, Wouters, Greet, Van den Berghe   +7 more
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Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression

Journal of Physical Fitness and Sports Medicine
The mitochondria are highly plastic organelles. Exercise training alters mitochondrial dynamics (mitochondrial fission and fusion) in skeletal muscles and improves overall mitochondrial function by altering mitochondrial morphology and forming new ...
Hisashi Takakura, Hitomi Banba, Tatsuya Yamada, Rikuhide Koma, Tsubasa Shibaguchi, Yudai Nonaka, Kazumi Masuda   +6 more
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GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance

Neurobiology of Disease, 2009
Mutations in the GDAP1 gene lead to recessively or dominantly inherited peripheral neuropathies (Charcot–Marie–Tooth disease; CMT). Here, we demonstrate that GDAP1 is a mitochondrial fission factor whose activity is dependent on the fission factors Drp1 ...
Axel Niemann, Konstanze Marion Wagner, Marcel Ruegg, Ueli Suter   +3 more
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MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses

Scientific Reports, 2019
The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration.
Alexander Kreymerman, David N. Buickians, Michael M. Nahmou, Tammy Tran, Joana Galvao, Yan Wang, Nicholas Sun, Leah Bazik, Star K. Huynh, In-Jae Cho, Tomasz Boczek, Kun-Che Chang, Noelia J. Kunzevitzky, Jeffrey L. Goldberg   +13 more
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