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Markers of clinical and mitochondrial adaptation in response to moderate intensity continuous training: A systematic review and meta-analysis. [PDF]
PLoS OneVabishchevich V, Smith RT, Bittel AJ.
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Evaluation of the role of mitofusin‐1 and mitofusin‐2 in periodontal disease
Journal of Periodontology, 2023AbstractBackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria‐endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation.
Ömer Alperen Kırmızıgül +5 more
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Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis
Kidney International, 2022Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.
Divya Bhatia +6 more
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Reproductive Sciences, 2022
Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
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Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
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Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
Science, 2004Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria).
Takumi Koshiba +2 more
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Nature, 2008Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
Luca Scorrano
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Relationship between mitofusin 2 and cancer
2019Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra +3 more
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