Results 231 to 240 of about 17,983 (257)

Mitofusin-2 is a novel direct target of p53

Biochemical and Biophysical Research Communications, 2010
The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang, Xiaofei, Cheng, Jianju, Lu, Jianfeng, Wei, Guanghou, Fu, Feng, Zhu, Changku, Jia, Lin, Zhou, Haiyang, Xie, Shusen, Zheng   +9 more
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Role of mitofusin 2 in cardiovascular oxidative injury

Journal of Molecular Medicine, 2010
Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
openaire   +2 more sources

Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development

2011
Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development. When Mfn1 and Mfn2 were each conditionally knocked out from the cerebellum, Purkinje cells in Mfn2 deficient cerebellum during development had undergone neurodegeneration ...
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Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

Science Signaling, 2009
A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa, Hiroyuki, Oshiumi, Makoto, Takeda, Naotada, Ishihara, Yusuke, Yanagi, Tsukasa, Seya, Shun-ichiro, Kawabata, Takumi, Koshiba   +7 more
openaire   +2 more sources

The Role of Mitofusins in the Osteoclast Lineage

2019
Mitochondria exist in a highly dynamic network in many cell types, and mutations in mitochondrial transmembrane GTPase mitofusin2 (MFN2), a key factor that mediates mitochondrial tethering, cause defects in the nervous system. Intriguingly, the skeleton has been overlooked in patients with such mutations.
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Mitofusin-2 Regulates Platelet Mitochondria and Function

Circulation Research
BACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele ( MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are associated with reduced platelet MFN2 RNA expression and platelet ...
Shancy Jacob, Yasuhiro Kosaka, Seema Bhatlekar, Frederik Denorme, Haley Benzon, Alexandra Moody, Victoria Moody, Emilia A. Tugolukova, Grayson Hull, Nina Kishimoto, Bhanu K. Manne, Li Guo, Rhonda Souvenir, Brayden J. Seliger, Alicia S. Eustes, Kelly Hoerger, Neal D. Tolley, Amir N. Fatahian, Sihem Boudina, David C. Christiani, Yongyue Wei, Can Ju, Robert A. Campbell, Matthew T. Rondina, E. Dale Abel, Paul F. Bray, Andrew S. Weyrich, Jesse W. Rowley   +27 more
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E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

Molecular Cell, 2023
Vincent Anton, Tania Simöes, Reinhard Büttner   +2 more
exaly  

Deubiquitylating mitofusin

Nature Reviews Molecular Cell Biology, 2013
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Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity

Virulence, 2021
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo   +2 more
exaly  

Research Progress of Mitofusin-2*

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010
Guang-Ju ZHAO, Zhong-Qiu LU, Yong-Ming YAO   +2 more
openaire   +1 more source