Results 31 to 40 of about 96,831 (392)

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa [PDF]

, 2018
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
A Criollo, A Hamacher-Brady, A Hamacher-Brady, A Rita Di, A Rita Di, A Rozenknop, A Sali, A Sprenger, A Stolz, A Tanaka, AY Abramov, B Richter, C Margreitter, D Knight, DW Choi, EM Valente, F Strappazzon, F Strappazzon, F Strappazzon, F Strappazzon, G Ashrafi, G Xu, GA Khoury, GP Leboucher, H Sandoval, H Tomita, H Zhou, I Matic, I Novak, J Kitchen, JJ Lemasters, JL Parsons, JM Heo, K Sugawara, K Yamano, L Liu, LA Kane, M Campanella, M Karbowski, M Laforge, M Lazarou, M Pasi, M Pilli, M Tiberti, M Tiberti, MJ Abraham, MP Williamson, N Bakkar, N Shembade, NC Chan, P Bjelkmar, P Wild, Q Zhong, RK Dagda, S Inoue, S Piana, T Kitada, T Murakawa, T Tatsuta, TN Nguyen, V Cianfanelli, VV Rogov, VV Rogov, VV Rogov, W Zhang, Y Chen, Y Ichimura, Y Wei, Y Xue, Y Yuan, Y Zhu   +70 more
core   +4 more sources

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Journal of Biomedical Sciences, 2023
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues.
Lei Liu, Yanjun Li, Guo Chen, Quan Chen
semanticscholar   +1 more source

Receptor-mediated mitophagy [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Mitochondria are essential organelles that supply ATP through oxidative phosphorylation to maintain cellular homeostasis. Extrinsic or intrinsic agents can impair mitochondria, and these impaired mitochondria can generate reactive oxygen species (ROS) as byproducts, inducing cellular damage and cell death.
Yamaguchi, Osamu, Murakawa, Tomokazu, Nishida, Kazuhiko, Otsu, Kinya   +3 more
openaire   +5 more sources

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy

Cell Reports, 2019
Summary: Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast.
Tomokazu Murakawa, Koji Okamoto, Shigemiki Omiya, Manabu Taneike, Osamu Yamaguchi, Kinya Otsu   +5 more
doaj   +1 more source

Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

International Journal on Biological Sciences, 2023
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury.
Q. Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chao-jun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Min-fang Zhang, Jiayi Cheng, L. Gu, S. Mou, Z. Ni   +16 more
semanticscholar   +1 more source

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1 [PDF]

, 2014
Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the ...
A Follenzi, A Orvedahi, A Romagnoli, C Behrends, C Van Humbeeck, C Vives-Bauza, D Popovic, DP Narendra, EF Blommaart, F Cecconi, F Cecconi, F Nazio, F Nazio, F Strappazzon, F Strappazzon, G M Fimia, G Twig, GM Fimia, H Sandoval, J Jin, J Lippincott-Schwartz, JY Lee, K Okamoto, K Okatsu, M Campanella, M Campanella, M Corrado, M Cozzolino, M Kundu, M Piacentini, N Narendra, P Grumati, PA Andreux, PO Seglen, R Nardacci, RL Schweers, S Campello, S Geisler, S Hasson, S Pankiv, S Pistor, T Itoh, T Johansen, T Kanki, V Choubey, V Cianfanelli, Y Kabeya   +46 more
core   +7 more sources

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy [PDF]

Autophagy, 2016
Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian ...
Ming, Chen, Ziheng, Chen, Yueying, Wang, Zheng, Tan, Chongzhuo, Zhu, Yanjun, Li, Zhe, Han, Linbo, Chen, Ruize, Gao, Lei, Liu, Quan, Chen   +10 more
openaire   +2 more sources

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research [PDF]

, 2015
Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood.
Ainscow, Amchenkova, Bakeeva, Bazil, Beard, Bernardi, Brand, Braschi, Busch, Cagalinec, Castanier, Chan, Chen, Chen, Chen, Chouhan, Cipolat, Cortassa, das Neves, De Marchi, Dedkova, Denton, Denton, Ehses, Estaquier, Figge, Fischer, Frezza, Friedman, Gilkerson, Gilkerson, Gomes, Gottlieb, Grandemange, Groen, Harrison, Head, Hemion, Imai, Jahani-Asl, Jahani-Asl, Jimenez, Johnston, Johnston, Junesch, Kim, Kowald, Krapivsky, Laar, Lee, Legros, Lemasters, Liesa, Liu, Liu, Logan, Magnus, Mai, Malli, Maltecca, McBride, McCormack, Meeusen, Mishra, Mitra, Mitra, Mouli, Murphy, Nakada, Narendra, Neuspiel, Olichon, Ong, Ono, Parone, Partikian, Patel, Patergnani, Patten, Picard, Picard, Qian, Rafelski, Rafelski, Rambold, Rizzuto, Rizzuto, Rodell, Rolland, Saa, Sahimi, Skulachev, Skulachev, Soboll, Soga, Song, Soubannier, Stauffer, Sukhorukov, Szabadkai, Tondera, Twig, Twig, van der Bliek, Verkman, Vinnakota, Viola, Wan, Westrate, Wikstrom, Wikstrom, Wilkens, Wu, Wu, Youle, Zemirli, Zhang, Zhu   +117 more
core   +2 more sources

Regulatory Mechanisms of Mitochondrial Autophagy: Lessons From Yeast

Frontiers in Plant Science, 2019
Mitochondria produce the majority of ATP required by cells via oxidative phosphorylation. Therefore, regulation of mitochondrial quality and quantity is important for maintaining cellular activities.
Kentaro Furukawa, Aleksei Innokentev, Tomotake Kanki   +2 more
doaj   +1 more source