The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α2 receptor activity in vitro and in vivo. [PDF]
Eur J PharmacolMitragynine, an alkaloid present in the leaves of Mitragyna speciosa (kratom), has a complex pharmacology that includes low efficacy agonism at μ-opioid receptors (MORs).
Obeng S +21 more
europepmc +2 more sources
Identification of “Kratom” (Mitragyna speciosa) Alkaloids in Commercially Available Products [PDF]
, 2017 “Kratom” is the common name for the botanical mitragyna speciosa. It is a tree native to Southeast Asia in which leaves contain the psychoactive alkaloids mitragynine and 7-hydroxymitragynine. Kratom is often ingested as teas, chewed, or smoked.
Grzymkowski, Julia +2 more
core +1 more source
Suspected Driving Under the Influence Case Involving Mitragynine [PDF]
Journal of Analytical Toxicology, 2018 Mitragynine is a novel psychoactive substance (NPS) that has emerged as a designer opioid being distributed on the street. Mitragynine, also known as kratom, has dose-dependent pharmacological effects and possesses both stimulant-like and sedative effects due to dual-binding of α-adrenergic and μ-opioid receptors.
openaire +2 more sources
A case of fatal overdose involving both hydromorphone and kratom
Journal of Forensic Sciences, Volume 69, Issue 1, Page 355-358, January 2024.Abstract Kratom is a plant originating in Southeast Asia that has been used for its dose‐dependent stimulant and opioid effects. The main active compound in kratom is mitragynine, an alkaloid with affinity for the mu‐opioid receptor. Toxicity and fatalities related to kratom use have increased substantially in recent years.
Thomas Shi, Jennifer L. Shea
wiley +1 more source
Medical Journal of Australia, Volume 222, Issue 5, Page 259-261, March 2025.
Shane Darke +4 more
wiley +1 more source
Effect of Kramecyne on the Inflammatory Response in Lipopolysaccharide-Stimulated Peritoneal Macrophages [PDF]
, 2013 Kramecyne is a new peroxide, it was isolated from Krameria cytisoides, methanol extract, and this plant was mostly found in North and South America. This compound showed potent anti-inflammatory activity; however, the mechanisms by which this compound ...
E. Sánchez-Miranda +3 more
core +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth. (kratom). It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain.
Nur Aisyah Khairul Annuar +10 more
semanticscholar +1 more source
Uji Efek Sedatif Ekstrak N-heksan Dari Daun Kratom (Mitragyna Speciosa Korth.) Pada Mencit Jantan Galur Balb/c [PDF]
, 2013 Insomnia is a sleep disorder that can cause a variety of serious health problemsrequiring treatment. The using of synthetic drugs have dangerous side effects than therapywhich is resulted. Therefore, alternative treatments which derived from natural such
Hidayati, A. (Anna)
core +1 more source
Profile, effects, and toxicity of novel psychoactive substances: A systematic review of quantitative studies [PDF]
, 2017 OBJECTIVE: To investigate the profile, effects, and toxicity of novel psychoactive substances (NPS). METHODS: A systematic literature review was conducted between May 2015 and February 2016 and included 19 databases.
Antonowicz +35 more
core +2 more sources
Effect of short-term ingestion of the methanolic extract of mitragyna speciosa on sperm quality in mice [PDF]
, 2011 Mitragyna speciosa (MS) which is known as “Ketum” in Malaysia and “Kratom” in Thailand is a tropical plant indigenous to Southeast Asia. The leaves of MS have been used by natives of these countries for their opium-like effects and cocaine-like ...
Abdul Kadir, Arifah +3 more
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