Results 1 to 10 of about 24,579 (198)

Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys [PDF]

Frontiers in Pharmacology, 2015
Dizocilpine (MK-801) is a noncompetitive NMDA antagonist that induces schizophrenic-like effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents.
Patricia G Saletti, Rafael S Maior, Etsuro eHori, Hisao eNishijo, Carlos eTomaz, Carlos eTomaz   +5 more
doaj   +8 more sources

Behavioral features and disorganization of oscillatory activity in C57BL/6J mice after acute low dose MK-801 administration [PDF]

Frontiers in Neuroscience, 2022
Low dose acute administration of N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 is widely used to model cognition impairments associated with schizophrenia (CIAS) in rodents. However, due to no unified standards for animal strain, dose, route of
Keke Cui, Keke Cui, Zhipeng Yu, Le Xu, Wangcong Jiang, Luwan Wang, Xiangqun Wang, Dandan Zou, Jiajie Gu, Feng Gao, Xiaoqing Zhang, Xiaoqing Zhang, Xiaoqing Zhang, Zhengchun Wang, Zhengchun Wang, Zhengchun Wang   +15 more
doaj   +2 more sources

Intra-accumbens injection of a dopamine aptamer abates MK-801-induced cognitive dysfunction in a model of schizophrenia. [PDF]

PLoS ONE, 2011
Systemic administration of the noncompetitive NMDA-receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia.
Matthew R Holahan, Dan Madularu, Erin M McConnell, Ryan Walsh, Maria C DeRosa   +4 more
doaj   +12 more sources

The Effects of Poria cocos on Rho Signaling-Induced Regulation of Mobility and F-Actin Aggregation in MK-801-Treated B35 and C6 Cells [PDF]

Behavioural Neurology, 2022
Background and Aim. We recently investigated whether Poria cocos water extract modulates ketamine-induced Rho signaling regulation and reverses ketamine-inhibited cell mobility and F-actin reconstruction in B35 and C6 cells.
Yi-Chyan Chen, Chang-Ti Lee, Fu-Ming Tsai, Mao-Liang Chen   +3 more
doaj   +2 more sources

Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats [PDF]

Neurobiology of Disease, 2022
Background: Few treatments exist for the cognitive symptoms of schizophrenia. Pharmacological agents resulting in glutamate N-methyl-d-aspartate (NMDA) receptor hypofunction, such as MK-801, mimic many of these symptoms and disrupt neural activity ...
Nancy C. Zepeda, Lindsey M. Crown, Sasha Medvidovic, Wooseong Choi, Megha Sheth, Matthew Bergosh, Raymond Gifford, Caroline Folz, Phillip Lam, Gengxi Lu, Robert Featherstone, Charles Y. Liu, Steven J. Siegel, Darrin J. Lee   +13 more
doaj   +2 more sources

Functional ultrasound imaging and prewhitening analysis reveal MK-801-induced disruption of brain network connectivity [PDF]

Frontiers in Pharmacology
BackgroundDisruption of N-methyl-D-aspartate receptor (NMDAR) activity within the septohippocampal network - a critical circuit that includes the hippocampus, medial prefrontal cortex (mPFC) and other nuclei - is believed to contribute to learning and ...
Erik Hakopian, Argishti E. Stepanian, Shan Zhong, Shan Zhong, Kofi A. Agyeman, Kofi A. Agyeman, Nancy Zepeda, Kevin Wu, Charles Liu, Charles Liu, Charles Liu, Charles Liu, Darrin J. Lee, Darrin J. Lee, Darrin J. Lee, Darrin J. Lee, Vassilios Christopoulos, Vassilios Christopoulos, Vassilios Christopoulos, Vassilios Christopoulos   +19 more
doaj   +2 more sources

Poria cocos Ethanol Extract Restores MK-801-Induced Cytoskeleton Regulation in Neuro2A and IMR-32 Cells and Locomotor Hyperactivity in C57BL/6 Mice by Modulating the Rho Signaling Pathway [PDF]

Current Issues in Molecular Biology
Poria cocos extract attenuates MK-801-induced hyperactivity via RhoA/ROCK1 pathway modulation in mice. Background/Objectives: Poria cocos (P. cocos), a traditional East Asian medicinal mushroom, serves as a medicine and nutritional supplement, has been ...
Ya-Ying Chang, Cheng-Wei Lu, Tzu-Yu Lin, I-Shiang Tzeng, Yi-Chyan Chen, Mao-Liang Chen   +5 more
doaj   +2 more sources

MK-801-exposure induces increased translation efficiency and mRNA hyperacetylation of Grin2a in the mouse prefrontal cortex [PDF]

Epigenetics
Acute exposure to MK-801, the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, induces schizophrenia-like behavioural changes in juvenile male mice. However, the effects of acute MK-801 exposure on brain gene expression at the translation
Liting Xue, Jialu Zhao, Xu Liu, Tian Zhao, Ying Zhang, Haihong Ye   +5 more
doaj   +2 more sources

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia [PDF]

Frontiers in Cellular Neuroscience, 2022
Schizophrenia is a severe mental disorder characterized by positive, negative, and cognitive symptoms. Cognitive symptoms are a kind of symptoms with high incidence and great impact on patients. There is no effective treatment in clinical practice.
Jinwei Xu, Yaohao Li, Biqing Tian, Haiying Liu, Shengxi Wu, Wenting Wang   +5 more
doaj   +2 more sources

Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis [PDF]

Biomedicines, 2023
MK-801, also called dizocilpine, is an N-methyl-D-aspartate (NMDA) receptor antagonist widely used in animal research to model schizophrenia-like phenotypes.
Thiago C. Moulin, Tijana Stojanovic, Rasika P. Rajesh, Tirusha Pareek, Laura Donzelli, Michael J. Williams, Helgi B. Schiöth   +6 more
doaj   +2 more sources