Results 91 to 100 of about 24,579 (198)

The role of NMDA receptors in rat propofol self-administration

BMC Anesthesiology, 2020
Background Propofol is among the most frequently used anesthetic agents, and it has the potential for abuse. The N-methyl-D-aspartate (NMDA) receptors are key mediators neural plasticity, neuronal development, addiction, and neurodegeneration.
Bei-ping Chen, Xi-xi Huang, Dong-mei Dong, Hui Wu, Tian-qi Zhu, Ben-fu Wang   +5 more
doaj   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Prevalence Rates of Frequent Dream Recall and Nightmares by Age, Gender and Sleep Duration in 16 Countries

Journal of Sleep Research, Volume 35, Issue 1, February 2026.
ABSTRACT The present study aimed to describe the prevalence rates of frequent (i.e., at least weekly) dream recall and nightmares with consideration for differences in age, gender and sleep duration in 16 countries using equivalent assessment methods.
Courtney J. Bolstad, Bjørn Bjorvatn, Ngan Yin Chan, Frances Chung, Yves Dauvilliers, Luigi De Gennaro, Colin A. Espie, Brigitte Holzinger, Yuichi Inoue, Maria Korman, Adrijana Koscec Bjelajac, Anne‐Marie Landtblom, Tainá Macêdo, Kentaro Matsui, Ilona Merikanto, Charles M. Morin, Sérgio Mota‐Rolim, Thomas Penzel, Giuseppe Plazzi, Cátia Reis, Serena Scarpelli, Yun Kwok Wing, Michael R. Nadorff   +22 more
wiley   +1 more source

NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: Complex relationships with behaviour

Neurobiology of Disease, 2020
Background: NMDAr antagonists induce disturbances to gamma frequency oscillations, including increasing ongoing gamma activity and reducing evoked gamma oscillations.
Matthew R. Hudson, Elysia Sokolenko, Terence J. O'Brien, Nigel C. Jones   +3 more
doaj   +1 more source

Synthetic Hydrogels Incorporating Hydrolytic/Nonhydrolytic Macromer Ratios Exhibit Improved Tunability of In Vivo Degradation and Immune Responses

Advanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.
A synthetic 4‐arm maleimide‐terminated poly(ethylene glycol) (PEG‐4MAL) hydrogel system that combines hydrolytic ester‐linked macromer (PEG‐4eMAL) with nondegradable amide‐linked macromer (PEG‐4aMAL) in various stoichiometric ratios to tune the degradability rate. The macromers are crosslinked with dithiothreitol via thiol‐maleimide click reaction. The
Michael D. Hunckler, Sophia Kioulaphides, Karen E. Martin, Angelica L. Torres, Graham F. Barber, Stephen W. Linderman, Rebecca S. Schneider, Andrés J. García   +7 more
wiley   +1 more source

NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice [PDF]

, 2016
Experiencing psychosocial stress inearly life, suchas social isolationstress (SIS), is knowntohavenegative enduring effects on the development of the brain and behavior.
Amini-Khoei, Hossein., Amiri, Shayan., Azizi, Romina., Dehpour, Ahmad Reza., Ejtemaei Mehr, Shahram., Ghazi-Khansari, Mahmoud., Haj-Mirzaian, Arya., Momeny, Majid., Rahimi Balaei, Maryam., Shirzadian, Armin., Zarrinrad, Ghazaleh.   +10 more
core   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, Volume 13, Issue 6, 30 January 2026.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Involvement of Glutamate NMDA Receptors in the Acute, Long-Term, and Conditioned Effects of Amphetamine on Rat 50kHz Ultrasonic Vocalizations [PDF]

, 2015
BACKGROUND: Rats emit 50kHz ultrasonic vocalizations (USVs) in response to either natural or pharmacological pleasurable stimuli, and these USVs have emerged as a new behavioral measure for investigating the motivational properties of drugs.
COSTA G, MORELLI M, SIMOLA N
core   +1 more source

Neural mechanisms of MK-801 induced sensitisation [PDF]

, 2016
Behavioural sensitisation describes the progressive and enduring augmentation of a drug-induced response that develops with repeated exposure. Sensitisation is a putative mechanism in the pathophysiology of drug addiction and neuropsychiatric disorders such as schizophrenia.
openaire   +2 more sources