Results 51 to 60 of about 24,579 (198)
Incomplete block of NMDA receptors by intracellular MK-801 [PDF]
Neuropharmacology, 2018 NMDA receptors (NMDARs) are essential components in glutamatergic synaptic signaling. The NMDAR antagonist MK-801 has been a valuable pharmacological tool in evaluating NMDAR function because it binds with high affinity to the NMDAR ion channel pore and is non-competitive with ligand binding.
Sun, Weinan +3 more
openaire +6 more sources
Frontiers in Pharmacology, 2013 Antagonism of N-methyl-D-aspartate (NMDA) receptors by phencyclidine is thought to underlie its ability to induce a schizophrenia-like syndrome in humans, yet evidence indicates it has a broader pharmacological profile.
Wendy K Adams +3 more
doaj +1 more source
Protective effect of resveratrol on kidney and liver histopathology induced by nmda receptor antagonist mk-801 in mice [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019 TMK-801 is an antagonist of N-methyl-D-aspartate (NMDA) receptors. Sub-chronic administration of 1 mg / kg dose of MK-801 resulted in schizophrenia-like symptoms and degeneration in the brain of mice.
Murat Sırrı AKOSMAN +2 more
doaj +1 more source
Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning [PDF]
, 2015 RATIONALE: Dopamine D1-like receptor signalling is involved in contextual fear conditioning, but the brain regions involved and its role in other contextual fear memory processes remain unclear.
Bast, Tobias +8 more
core +4 more sources
Frontiers in Cellular Neuroscience, 2015 As a multifactorial disease, the underlying causes of schizophrenia require analysis by multiplex methods such as proteomics to allow identification of whole protein networks.
Paul C Guest +6 more
doaj +1 more source
Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. [PDF]
PLoS ONE, 2011 The role of 5-HT₇ receptor has been demonstrated in various animal models of mood disorders; however its function in cognition remains largely speculative.
Pascal Bonaventure +7 more
doaj +1 more source
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
The effect of MK-801 on openfield activities and object exploration and its sex difference [PDF]
, 1998 The present study investigated the effect of MK-801 on openfield activities and object exploratory behavior in a circular openfield by using Sprague-Dawley rats.
Kishida Akemi +3 more
core +1 more source
HOWLish: a CNN for automated wolf howl detection
Remote Sensing in Ecology and Conservation, EarlyView.Automated detection of wolf howls presents a great opportunity for large‐scale passive acoustic monitoring of wolf populations. Here we present HOWLish, a CNN trained for automated wolf howl detection, based on thousands of hours of soundscapes recorded in the wild.
Rafael Campos +3 more
wiley +1 more source
Psychiatry and Clinical Psychopharmacology, 2018 OBJECTIVES Nicotinic receptor systems are involved in a wide variety of behavioural functions, including cognitive function, and nicotinic medications, may provide beneficial treatment for cognitive dysfunctions such as schizophrenia.
Gokhan Unal, Feyza Aricioglu
doaj +1 more source