Results 61 to 70 of about 24,579 (198)

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Efficient, Reversible Lead Adsorption in a Thiol‐Decorated Zirconium‐Metal–Organic Framework

Small, EarlyView.
A thiol‐decorated Zr‐MOF, Zr‐DMSA, efficiently captures Pb(II) from water via mixed S/O chelation enabled by flexible “dangling” ligands, as revealed by solid‐state NMR and pair distribution function analyses. Treatment with 1 M HCl fully reverses Pb binding, regenerating the material for up to 10 consecutive adsorption–desorption cycles.
Timo M. O. Felder, Nazanin Taheri, Till Schertenleib, Anne F. S. Belin, Pattaraphon Rodlamul, Laura Piveteau, Mounir Mensi, Xiao‐Xin Gao, Paul J. Dyson, Mohammad K. Nazeeruddin, Wendy L. Queen   +10 more
wiley   +1 more source

Olanzapine Reverses MK-801-Induced Cognitive Deficits and Region-Specific Alterations of NMDA Receptor Subunits

Frontiers in Behavioral Neuroscience, 2018
Cognitive dysfunction constitutes an essential component in schizophrenia for its early presence in the pathophysiology of the disease and close relatedness to life quality of patients.
Xiao Liu, Xiao Liu, Xiao Liu, Jitao Li, Chunmei Guo, Hongli Wang, Yaxin Sun, Han Wang, Yun-Ai Su, Keqing Li, Keqing Li, Tianmei Si   +11 more
doaj   +1 more source

ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish [PDF]

, 2000
In this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light ...
Huston, Joseph P., Mattioli, Rosana, Spieler, Richard E.   +2 more
core   +4 more sources

Low dose MK-801 reduces social investigation in mice [PDF]

Pharmacology Biochemistry and Behavior, 2008
To characterize MK-801's effect on social behavior in mice, we examined adult male ICR mice for interaction with companion mice (juvenile male). Test mice were injected with either saline or MK-801 (0.1 mg/kg), and were tested 30 min later for their social behavior during a 5-min session.
Hong, Zou, Chenghao, Zhang, Qinglian, Xie, Manfang, Zhang, Junwei, Shi, Meilei, Jin, Lei, Yu   +6 more
openaire   +2 more sources

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

Frontiers in Pharmacology, 2018
Attention impairment is a common feature of Major Depressive Disorder (MDD), and MDD-associated cognitive dysfunction may play an important role in determining functional status among this patient population.
Todd M. Hillhouse, Christina R. Merritt, Douglas A. Smith, Manuel Cajina, Connie Sanchez, Joseph H. Porter, Alan L. Pehrson   +6 more
doaj   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Pathologically Activated Neuroprotection via Uncompetitive Blockade of \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin [PDF]

, 2010
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders.
Fu, Hongjun, Han, Yifan, Huang, Pingbo, Li, Chaoying, Li, Fushun, Li, Wenming, Luo, Jialie, Ma, Dik-Lung, Pang, Yuanping, Peoples, Robert W., Tang, Jing, Wang, Qinwen, Xia, Jun, Zhao, Yuming   +13 more
core   +1 more source

Accuracy of Freehand, Static, and Dynamic Computer‐Assisted Implant Placement: A Systematic Review and Meta‐Analysis

Journal of Periodontal Research, EarlyView.
This meta‐analysis finds that both static and dynamic computer‐assisted implant placement methods offer significantly better transfer accuracy than freehand placement. No clinically relevant accuracy differences were found between static and dynamic approaches.
Florian Sebastian Reiff, Annika Kroeger, Stefan Roehling, Christine Reiff, Moritz Kebschull   +4 more
wiley   +1 more source