Results 71 to 80 of about 24,579 (198)

In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [PDF]

, 2009
It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of NR2A-containing ...
Hardingham, G.E., Martel, M.-A., Wyllie, D.J.A.   +2 more
core   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Acute Administration of MK-801 in an Animal Model of Psychosis in Rats Interferes with Cognitively Demanding Forms of Behavioral Flexibility on a Rotating Arena

Frontiers in Behavioral Neuroscience, 2015
Patients with schizophrenia often manifest deficits in behavioral flexibility. Non-competitive NMDA receptor antagonists such as MK-801 induce schizophrenia-like symptoms in rodents, including cognitive functions.
Jan eSvoboda, Anna eStankova, Anna eStankova, Marie eEntlerova, Ales eStuchlik, Ales eStuchlik   +5 more
doaj   +1 more source

Relationship between sex and MK801\u27s effects in rats. [PDF]

, 2023
In this study, we are investigating the effects of MK-801 on male and female Sprague Dawley rats. According to D’Souza et al. (2001), females have a stronger reaction to MK-801 than males. Correspondingly, the current study measures the varied effects of
Foust, Seth, McCurry, Emily, Sanchez, Erica   +2 more
core  

Should “sisters” be doing it by themselves? Leadership, allyship, and mobilization for gender equality

Political Psychology, EarlyView.
Abstract While gender equality initiatives have historically been spearheaded by women, male allies' contribution is increasingly recognized—and challenged. Our article examines the pivotal yet neglected intersection of women's leadership and allyship for gender equality. Across two experiments with community samples (total N = 801), we investigate how
Emina Subašić, Michelle K. Ryan, Lisa Joye, Mitchell Young, Stephanie Hardacre, Katherine J. Reynolds, Nyla R. Branscombe   +6 more
wiley   +1 more source

Disseminated Corticolimbic Neuronal Degeneration Induced in Rat Brain by MK-801: Potential Relevance to Alzheimer's Disease

Neurobiology of Disease, 1998
Blockade ofN-methyl-d-aspartate (NMDA) glutamate receptors by MK-801 induces neuronal degeneration in the posterior cingulate/retrosplenial cortex and other corticolimbic regions although damage in the latter has not been adequately characterized.
D.F. Wozniak, K. Dikranian, M.J. Ishimaru, A. Nardi, T.D. Corso, T. Tenkova, J.W. Olney, A.S. Fix   +7 more
doaj   +1 more source

Social determinants of health and intensive care unit admission rates and outcomes for children, Australia, 2013–2020: analysis of national registry data

Medical Journal of Australia, Volume 222, Issue 8, Page 412-421, May 2025.
Abstract Objectives To investigate the influence of non‐medical social determinants of health on rates of admission and outcomes for children admitted to intensive care units (ICUs) in Australia. Study design Retrospective cohort study; analysis of Australian and New Zealand Paediatric Intensive Care Registry data.
Katie M Moynihan, Vanessa Russ, Darren Clinch, Lahn Straney, Johnny Millar, Marino Festa, Natasha Nassar, Shreerupa Basu, Thavani Thavarajasingam, Debbie Long, Paul J Secombe, Anthony J Slater, for the Australian and New Zealand Intensive Care Society Paediatric Study Group and Centre for Outcomes and Resource Evaluation   +12 more
wiley   +1 more source

Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity

Frontiers in Psychiatry, 2011
NMDA receptor (NMDAR) antagonists, such as phencyclidine, ketamine or dizocilpine (MK-801) are commonly used in psychiatric drug discovery in order to model several symptoms of schizophrenia, including psychosis and impairments in working memory.
Tamás eKiss, William E Hoffmann, Liam eScott, Thomas T Kawabe, Anthony J Milici, Erik A Nilsen, Mihály eHajós   +6 more
doaj   +1 more source

Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy

IBRO Reports, 2020
Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies.
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +9 more
doaj   +1 more source

Altered GABAergic, glutamatergic and endocannabinoid signaling is accompanied by neuroinflammatory response in a zebrafish model of social withdrawal behavior

Frontiers in Molecular Neuroscience, 2023
IntroductionDeficits in social communication are in the core of clinical symptoms characterizing many neuropsychiatric disorders such as schizophrenia and autism spectrum disorder.
Panagiotis Perdikaris, Catherine R. Dermon   +1 more
doaj   +1 more source