Results 81 to 90 of about 24,579 (198)

Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells [PDF]

, 2013
During cortical development, N-methyl D-aspartate (NMDA) receptors are highly involved in neuronal maturation and synapse establishment. Their implication in the phenomenon of excitotoxicity has been extensively described in several neurodegenerative ...
Baatout, Sarah, Benotmane, Mohammed Abderrafi, De Saint-Georges, Louis, Leyns, Luc, Pani, Giuseppe, Samari, Nada   +5 more
core   +2 more sources

Cause‐specific mortality after a diagnosis of ductal carcinoma in situ: Associations with screening and socio‐economic status

International Journal of Cancer, Volume 158, Issue 4, Page 873-883, 15 February 2026.
What's new? Ductal carcinoma in situ (DCIS) fails to progress to invasive breast cancer (IBC) in about four‐fifths of women. Nonetheless, once advanced to IBC, risk of death increases. Here, the authors investigated breast cancer mortality in Dutch women with DCIS in light of potential associations with socioeconomic status (SES) and DCIS detection ...
Renée S. J. M. Schmitz, Alexandra W. van den Belt‐Dusebout, Maartje van Seijen, Ellen A. J. Verschuur, Frederieke H. van Duijnhoven, Michael Schaapveld, Esther H. Lips, Jelle Wesseling, Marjanka K. Schmidt   +8 more
wiley   +1 more source

Inducible nitric oxide inhibitors block NMDA antagonist-stimulated motoric behaviors and medial prefrontal cortical glutamate efflux

Frontiers in Pharmacology, 2015
Nitric oxide (NO) plays a critical role in the motoric and glutamate releasing action of N-methyl-D-aspartate (NMDA)-antagonist stimulants. Earlier studies utilized neuronal nitric oxide synthase inhibitors (nNOS) for studying the neurobehavioral effects
Hadley C Bergstrom, Altaf eDavesh, Altaf eDavesh, S Paul Berger   +3 more
doaj   +1 more source

CDPPB reverses an NMDA receptor antagonist-induced deficit in inhibitory avoidance and conditioned taste aversion learning in rats [PDF]

Title from PDF of title page (University of Missouri--Columbia, viewed on November 3, 2010).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the ...
Wade, Stephanie Lynn, 1983-
core   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Neuroprotection by Combined Administration with Maslinic Acid, a Natural Product from Olea europaea, and MK-801 in the Cerebral Ischemia Model

Molecules, 2016
Glutamate-mediated excitotoxicity is a major cause of ischemic brain damage. MK-801 confers neuroprotection by attenuating the activation of the N-methyl-d-aspartate (NMDA) receptor, but it failed in clinical use due to the short therapeutic window. Here
Yisong Qian, Xuzhen Tang, Teng Guan, Yunman Li, Hongbin Sun   +4 more
doaj   +1 more source

Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]

, 2013
NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H, Deng, W, Guo, F, Jiang, P, Pleasure, DE   +4 more
core   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia

Journal of Pharmacological Sciences, 2009
We studied the effects of antipsychotics and a hypnotic on sleep disturbance in schizophrenia using an animal model of the disease. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were chronically implanted into the cortex and the ...
Takayuki Ishida, Yoshihito Obara, Chiaki Kamei   +2 more
doaj   +1 more source