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Lynch Syndrome Associated with Two MLH1 Promoter Variants and Allelic Imbalance of MLH1 Expression [PDF]

Human Mutation, 2015
© 2015 The Authors. **Human Mutation published by Wiley Periodicals, Inc. Lynch syndrome is a hereditary cancer syndrome caused by a constitutional mutation in one of the mismatch repair genes.
Robyn Lynne Ward, Jason Wong
exaly   +2 more sources

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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Cancer Cell, 2021
Jerry W Shay, Silvia Siteni, Mingyi Chen   +2 more
exaly  

Differential outcomes and immune checkpoint inhibitor response among endometrial cancer patients with MLH1 hypermethylation versus MLH1 “Lynch-like” mismatch repair gene mutation

Gynecologic Oncology, 2023
Alex Farrell, Sharon Wu
exaly  

MLH1-methylated endometrial cancer under 60 years of age as the “sentinel” cancer in female carriers of high-risk constitutional MLH1 epimutation

Gynecologic Oncology, 2023
Tiffani A Demarco, Rakesh Biswas
exaly  

Testing region selection and prognostic analysis of MLH1 promoter methylation in colorectal cancer in China

Gastroenterology Report, 2023
Xinhui Fu, Zhiting Chen, Hanjie Lin
exaly  

Chromate exposure induces DNA hypermethylation of the mismatch repair gene MLH1 in lung cancer

Molecular Carcinogenesis, 2020
Mitsuhiro Tsuboi
exaly  

Evidence for heritable predisposition to epigenetic silencing of MLH1

International Journal of Cancer, 2007
Heather Hampel, Paul Goodfellow
exaly  

Contribution of MLH1 constitutional methylation for Lynch syndrome diagnosis in patients with tumor MLH1 downregulation

Cancer Medicine, 2018
Joana Guerra, Pedro Pinto, Manuela Pinheiro   +2 more
exaly  

Tumours fromMSH2 mutation carriers show loss of MSH2 expression but many tumours fromMLH1 mutation carriers exhibit weak positive MLH1 staining

Journal of Pathology, 2005
Elisabeth Mangold, Stefan Aretz, Nicolaus Friedrichs   +2 more
exaly