Results 201 to 210 of about 44,743 (233)

Regulation of the MLH1–MLH3 endonuclease in meiosis [PDF]

Nature, 2020
SummaryDuring prophase of the first meiotic division, cells deliberately break their DNA. These DNA breaks are repaired by homologous recombination, which facilitates proper chromosome segregation and enables reciprocal exchange of DNA segments between homologous chromosomes, thus promoting genetic diversity in the progeny1.
Elda Cannavo, Roopesh Anand, Lepakshi Ranjha   +2 more
exaly   +7 more sources

Some of the next articles are maybe not open access.

Related searches:

MLH1/PMS2-deficient Endometrial Carcinomas in a Universally Screened Population: MLH1 Hypermethylation and Germline Mutation Status

International Journal of Gynecological Pathology, 2021
MLH1/PMS2 loss due to epigenetic hypermethylation of the MLH1 promoter is the most common cause of mismatch repair deficiency in endometrial carcinoma, and typically provides reassurance against an associated germline mutation. To further characterize the genetic features of MLH1/PMS2-deficient endometrial cancers, the departmental database was ...
Brett, Kurpiel, Martha S, Thomas, Mansoor, Mubeen, Kari L, Ring, Susan C, Modesitt, Christopher A, Moskaluk, Anne M, Mills   +6 more
openaire   +2 more sources

MLH1 and MSH2 Expression in Pterygia

Cornea, 2007
Pterygia have been reported to share some of the genetic defects seen in cancers, including microsatellite instability (MSI). We examined pterygia for the presence of proteins typically missing or defective in adenocarcinomas with MSI. We also performed microsatellite analysis on DNA from pterygia to test for instability in the size of the ...
Barbara G, Schneider, Deshdeepak, Sahni, Juan C, Torres, Nicholas, Dushku, Ted W, Reid   +4 more
openaire   +2 more sources

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.

Cancer research, 1999
An3 1 KAL I MutL homologue 1 (MLH1) is a member of the family of proteins required for DNA mismatch repair. Germ-line mutations in MLH1 lead to the cancer susceptibility syndrome hereditary nonpolyposis colorectal cancer (HNPCC). We generated mice carrying a null mutation in the Mlh1 gene.
W, Edelmann, K, Yang, M, Kuraguchi, J, Heyer, M, Lia, B, Kneitz, K, Fan, A M, Brown, M, Lipkin, R, Kucherlapati   +9 more
openaire   +1 more source

Association between the MLH1 gene and longevity

Human Genetics, 2006
Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity.
Dong Jo, Kim, Sang Mi, Yi, Seung Yeon, Lee, Heun Soo, Kang, Yoon-Ho, Choi, Yeong Wook, Song, Sang Chul, Park   +6 more
openaire   +2 more sources

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Cancer Cell, 2021
Junhong Guan, Changzheng Lu, Huiming Lu
exaly  

MLH1

2017
Timothy Kinsella, Kara Lynne Leonard
openaire   +1 more source

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

Cancer research, 1999
The DNA mismatch repair gene hMLH1 is reported to function in mutation avoidance, cell cycle checkpoint control, the cytotoxicity of various DNA-damaging agents, and transcription-coupled nucleotide excision repair. Formal proof of the involvement of hMLH1 in these processes requires single gene complementation.
A B, Buermeyer, C, Wilson-Van Patten, S M, Baker, R M, Liskay   +3 more
openaire   +1 more source

MLH1

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

MLH1

2015
Timothy Kinsella, Kara Lynne Leonard
openaire   +1 more source