Results 261 to 270 of about 156,368 (309)

Genes expression of metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis

Russian Journal of Genetics, 2011
Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with
N. L. Starodubtseva, V. V. Sobolev, A. G. Soboleva, A. A. Nikolaev, S. A. Bruskin   +4 more
openaire   +1 more source

Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.

Anticancer research, 2004
The members of the matrix metalloproteinase family (MMP) have the ability to degrade macromolecules of the extracellular matrix and are responsible for tumor invasion and infiltration, limiting the effectiveness of the neurosurgical resection of brain tumors. Among the glial brain tumors, astrocytomas and oligodendrogliomas are the most important tumor
V, Thorns, G F, Walter, C, Thorns
openaire   +1 more source

MMPs Inhibitors: New Succinylhydroxamates with Selective Inhibition of MMP‐2 over MMP‐3.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Valérie, Marcq, Catherine, Mirand, Martine, Decarme, Hervé, Emonard, William, Hornebeck   +4 more
openaire   +2 more sources

[Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis].

Genetika, 2011
Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with
N L, Starodubtseva, V V, Sobolev, A G, Soboleva, A A, Nikolaev, S A, Bruskin   +4 more
openaire   +1 more source

Regulation of matrix metalloproteinase (MMP) expression in cutis laxa fibroblasts: upregulation of MMP‐1, MMP‐3 and MMP‐9 genes but not of the MMP‐2 gene

British Journal of Dermatology, 1998
A major histopathological abnormality in cutis laxa (CL) is a paucity of elastic structures. The aim of this study was to investigate the gene expression levels of the major matrix degrading factors matrix metalloproteinase (MMP) 1, MMP-2, MMP-3 and MMP-9 in CL. The gene expression levels of MMP-1, MMP-2, MMP-3 and MMP-9 in cultured CL fibroblasts were
A, Hatamochi, K, Kuroda, H, Shinkai, H, Kohma, Y, Oishi, S, Inoue   +5 more
openaire   +2 more sources

Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3

Bioorganic & Medicinal Chemistry Letters, 2003
Phosphinic acid-based inhibitors of MMP-13 have been investigated with the aim of identifying potent inhibitors with high selectivity versus MMP-1. Independent variation of the substituents on a P(1)' phenethyl group and a P(2) benzyl group improved potencies in both cases around 3-fold over the unsubstituted parent.
Lawrence A, Reiter, Peter G, Mitchell, Gary J, Martinelli, Lori L, Lopresti-Morrow, Sue A, Yocum, James D, Eskra   +5 more
openaire   +2 more sources

Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression

Journal of Dermatological Science, 2001
Stasis dermatitis is a common disorder, which is a consequence of impaired venous drainage of the legs. It is characterized histologically by proliferation of small blood vessels in the papillary dermis. This neovascularization may lead occasionally to the formation of discrete papules due to inflammatory processes.
Herouy, Yared, Mellios, Philipp, Bandemir, Ellen, Dichmann, Stefan, Nockowski, Piotr, Schöpf, Erwin, Norgauer, Johannes   +6 more
openaire   +3 more sources

Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle

NeuroReport, 1999
Proteolytic enzyme expression was studied by matrix metalloproteinases (MMP) immunoreactivity (-IR) in muscle biopsies from patients with amyotrophic lateral sclerosis (ALS), spinal muscle atrophy (SMA) and chronic axonal neuropathies (CANP). In normal muscle MMP-2-, MMP-7-, and MMP-9-IR was localized at neuromuscular junctions, in vessels and nerve ...
B G, Schoser, D, Blottner
openaire   +2 more sources

MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2015
Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer.
Salo Tuula, Haglund Caj, Hagstrom Jaana, Kontio Risto, Virolainen Susanna, Atula Timo, Sorsa Timo, Salo Tuula, Häyry Valtteri, Salo Tuula, Haglund Caj, Hagstrom Jaana, Kontio Risto, Virolainen Susanna, Atula Timo, Sorsa Timo, Salo Tuula, Häyry Valtteri   +17 more
openaire   +2 more sources

Molecular Imaging of MMP Expression and Therapeutic MMP Inhibition

Academic Radiology, 2002
Matrix metalloproteinase (MMP), a family of proteolytic enzymes, are critically involved in tumor progression and angiogenesis (1). A number of MMP-inhibitors have been developed as cytostatic and antiangiogenic agents. Direct imaging of enzyme activity has only recently been proposed using near infrared fluorescence (NIRF) imaging and enzyme-sensitive
Christoph, Bremer, Ching-Hsuan, Tung, Ralph, Weissleder   +2 more
openaire   +2 more sources