Results 81 to 90 of about 956,533 (304)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Qualification testing of secondary sterilizable silver-zinc cells for use in the Jupiter atmospheric entry probe [PDF]

A series of qualification tests were run on the secondary, sterilizable silver oxide - zinc cell developed at the NASA Lewis Research Center to determine if the cell was capable of providing mission power requirements for the Jupiter atmospheric entry ...
Manzo, M. A.
core   +1 more source

Longitudinal profiles of Extensive Air Showers with inclusion of charm and bottom particles

, 2019
Charm and bottom particles are rare in Extensive Air Showers but the effect of its presence can be radical in the development of the Extensive Air Showers (EAS).
Gonçalves, Victor P., Muller, M. A.
core   +1 more source

Gas and surface diffusion in modified γ-alumina systems [PDF]

, 1989
The transport of pure gases through a microporous membrane is described. The alumina-based membrane (pores 2.5-4 nm) is suitable for Knudsen diffusion separation.
Burggraaf, A.J., Keizer, K., Uhlhorn, R.J.R.   +2 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Graphite fiber surface treatment to improve char retention and increase fiber clumping [PDF]

Composites containing carbon and graphite fibers can release fibers into the atmosphere during a fire. This release can potentially cause failure in some types of electrical equipment.
Paul, J. T., Jr., Weldy, W. E.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of Different Packaging on the Purine Content and Key Enzymes of Refrigerated Yellow Croaker (Larimichthys crocea)

Foods
In this study, we investigated the effects of air packaging, vacuum packaging and modified atmosphere packaging (CO2/N2: 80/20) on the purine metabolism and enzyme activities of refrigerated large yellow croakers.
Tiansheng Xu, Wenxuan Lu, Bohan Chen, Dapeng Li, Jing Xie   +4 more
doaj   +1 more source

The effect of storage conditions on formation of resistant starch polymorphs and crumb texture of a hot-dog type bakery product [PDF]

Journal on Processing and Energy in Agriculture, 2012
Effects of packing in modified atmosphere (MA, 30% CO2 and 70% N2) and storage in freezer and room temperature on the shelf-life of a hot-dog type bakery product were determined based on changes in both the content of resistant starch (RS) (quantified by
Kwasniewska-Karolak Izabella, Rosicka-Kaczmarek Justyna, Krala Lucjan   +2 more
doaj  

Toxicidade da combinação de dióxido de carbono e fosfina sob diferentes temperaturas para Tribolium castaneum Toxicity of the carbon dioxide and phosphine combination to Tribolium castaneum under different temperatures

Revista Brasileira de Engenharia Agrícola e Ambiental, 2010
O objetivo deste trabalho foi avaliar o efeito da temperatura sobre a toxicidade da combinação de dióxido de carbono e fosfina, para os estágios de desenvolvimento de Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). A toxicidade da combinação de
Raimundo W. S. Aguiar, Lêda R. D'A. Faroni, Raul N. C. Guedes, Adalberto H. Sousa, Adriano F. Rozado   +4 more
doaj   +1 more source