Results 131 to 140 of about 3,038,058 (339)

Molecular contamination study by interaction of a molecular beam with a platinum surface [PDF]

The capability of molecular beam scattering from a solid surface is analyzed for identification of molecular contamination of the surface. The design and setup of the molecular beam source and the measuring setup for the application of a phase sensitive ...
Nuss, H. E.
core   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P., Portelli, Michael A., Sayers, Ian   +2 more
core  

Variational Methods for Biomolecular Modeling

, 2016
Structure, function and dynamics of many biomolecular systems can be characterized by the energetic variational principle and the corresponding systems of partial differential equations (PDEs).
A Ivankin, A Jaramillo, A Warshel, AB Camley, B Lee, B Li, B Li, B Li, B Lu, B Lu, B Wang, BJ Reynwar, BR Brooks, C Mim, D Marsh, D Spoel Van Der, DG Thomas, DL Parton, E Gallicchio, E Gallicchio, EA Evans, F Campelo, FH Stillinger, FM Richards, FS Cohen, G Archontis, G-W Wei, G-W Wei, G-W Wei, GP Leser, GW Wei, HT McMahon, HY Lin, I Massova, I Park, IR Cooke, J Dzubiella, J Faraudo, J Gumbart, J Strain, J Wagoner, J Zimmerberg, JA Grant, JA Grant, JA Grant, JA Wagoner, JC Phillips, JC Stachowiak, JD Madura, JE Rothman, JMJ Swanson, K Farsad, K Lum, K Simons, KA Sharp, KM Callenberg, KS Kim, L-T Gao, LJ Pike, M Daily, M Feig, MD Huang, ME Davis, N Choudhury, N Gavish, NA Baker, NW Schmidt, O Sten-Knudsen, P Concus, P Grochowski, PB Canham, PW Bates, PW Bates, Q Du, Q Du, Q Du, Q Zheng, Q Zheng, R Brewster, R Brewster, R Parthasarathy, RA Pierotti, RE Skyner, RJ Ryham, S Choe, S Dai, S Li, S Osher, S Xu, S Zhao, S Zhao, SC Brenner, T Baumgart, T Kirchhausen, T Simonson, T Sollner, T Takahashi, T Witkowski, T-L Horng, V Luzhkov, VB Chu, W Geng, X Chen, X Chen, Y Tang, Y Wang, Y Wang, Y Wang, Y Zhao, YC Zhou, YC Zhou, Z Chen, Z Chen, Z Chen, ZY Yu   +114 more
core   +1 more source

Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors [PDF]

, 2019
Yunjiang Zhou, Shi Tang, Tingting Chen, Miaomiao Niu   +3 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Molecular identification of endophytic fungi associated with orchids from Mount Cameroon region

, 2021
Essomo Sylvie Etanke, Arrey Doris Besem, Afanga Yannick Afanga, Meshi Joice, Eneke Tambe Bechem, Fonge Beatrice Ambo   +5 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source