Results 11 to 20 of about 1,543,233 (247)

Molecular Formula Identification with SIRIUS [PDF]

Metabolites, 2013
We present results of the SIRIUS2 submission to the 2012 CASMI contest. Only results for Category 1 (molecular formula identification) were submitted. The SIRIUS method and the parameters used are briefly described, followed by detailed analysis of the results and a discussion of cases where SIRIUS2 was unable to come up with the correct molecular ...
Kai Dührkop, Kerstin Scheubert, Sebastian Böcker   +2 more
openaire   +3 more sources

Research Progress and Forensic Application of Postmortem Genetic Testing in Hereditary Cardiac Diseases

Fayixue Zazhi, 2022
Hereditary cardiac disease accounts for a large proportion of sudden cardiac death （SCD） in young adults. Hereditary cardiac disease can be divided into hereditary structural heart disease and channelopathies.
DONG Yi-ming, YANG Chen-teng, ZHANG Guo-zhong, CONG Bin   +3 more
doaj   +1 more source

Metabolomics Changes of Serum and Tissues in Mice Died of Acute Tetracaine Poisoning [PDF]

Fayixue Zazhi, 2021
Objective To study the changes of metabolites in serum and tissues （kidney, liver and heart） of mice died of acute tetracaine poisoning by metabolomics, to search for potential biomarkers and related metabolic pathways, and to provide new ideas for the ...
LIU Wen-qiao, BAI Rui, MA Chun-ling, et al.
doaj   +1 more source

Control effects of metabolites of endophytic fungus Alternaria sp. GHX-P17 on bacterial wilt and changes of protective enzymes in Pogostemon cablin

Guangxi Zhiwu, 2023
There is a long history to cultivate the Pogostemon cablin in Guangdong Province, and it is a famous medicinal material. The bacterial wilt is the important disease that impacts the production and quality of P. cablin.
Xiaoqing CHENG, Haoming JIANG, Yexuan CUI, Jinru LIN, Liguo WANG   +4 more
doaj   +1 more source

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

Frontiers in Pharmacology, 2020
A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse.
Xi Shen, Rongji Hui, Yixiao Luo, Hailei Yu, Suiyuan Feng, Bing Xie, Haitao Bi, Ewa Galaj, Bin Cong, Chunling Ma, Di Wen   +10 more
doaj   +1 more source

Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault

Forensic Sciences Research, 2019
In recent years, benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults (DFSA); however, barbiturates are also detected occasionally.
Di Wen, Yan Shi, Xiaoguang Zhang, Bing Xie, Wenqiao Liu, Feng Yu, Ping Xiang, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

Analytical Cellular Pathology, 2021
An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu, Weibo Shi, Yingmin Li, Shanyong Yi, Yang Li, Xia Liu, Bin Cong, Guanglong He   +7 more
doaj   +1 more source

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

Frontiers in Pharmacology, 2019
Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders.
Di Wen, Rongji Hui, Jian Wang, Xi Shen, Bing Xie, Miao Gong, Feng Yu, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source

Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons

Communications Chemistry, 2023
Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj   +1 more source

The Role of circTmeff-1 in Morphine Addiction Memory of Mice

Cells, 2023
In addition to the essential pharmacological effects of opioids, situational cues associated with drug addiction memory are key triggers for drug seeking.
Hailei Yu, Boyang Wen, Yun Lu, Bing Xie, Feng Yu, Minglong Zhang, Chunling Ma, Bin Cong, Di Wen, Haitao Bi   +9 more
doaj   +1 more source