Results 1 to 10 of about 395,686 (301)

A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation [PDF]

Kidney Research and Clinical Practice, 2023
Background Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant failure. Additional genetic parameters in donor-recipient matching could help improve
Felix Poppelaars, Siawosh K. Eskandari, Jeffrey Damman, Marc A. Seelen, Bernardo Faria, Mariana Gaya da Costa   +5 more
doaj   +1 more source

Molecular Motors–Nature’s Efficiency at Work

Reports in Advances of Physical Sciences, 2022
Nature has generated sophisticated and very efficient molecular motors, employed for nanoscale transport at the intracellular level. As a complementary tool to nanofluidics, these motors have been envisioned for nanotechnological devices.
Winfried Teizer
doaj   +1 more source

Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation

Cell Reports, 2021
Summary: Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive.
Supriya Swarnkar, Yosef Avchalumov, Isabel Espadas, Eddie Grinman, Xin-an Liu, Bindu L. Raveendra, Aya Zucca, Sonia Mediouni, Abhishek Sadhu, Susana Valente, Damon Page, Kyle Miller, Sathyanarayanan V. Puthanveettil   +12 more
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Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior

Frontiers in Cell and Developmental Biology, 2021
Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as
Saumya Yadav, Ambarish Kunwar
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Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

Acta Pharmaceutica Sinica B, 2021
Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin ...
Yi Qian, Meimei Zhao, Qinghua Han, Jingkang Wang, Lixi Liao, Heng Yang, Dan Liu, Pengfei Tu, Hong Liang, Kewu Zeng   +9 more
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Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

eLife, 2022
Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef, Hisashi Tadakuma, Kangmin Yan, Takashi Fujiwara, Kodai Fukumoto, Yuichi Kondo, Hiroko Takazaki, Rofia Boudria, Takuo Yasunaga, Hideo Higuchi, Keiko Hirose   +10 more
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Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
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A role for myosin VI in the localization of axonal proteins. [PDF]

PLoS Biology, 2011
In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites.
Tommy L Lewis, Tianyi Mao, Don B Arnold
doaj   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
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Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics

Marine Drugs, 2016
Unlike virtually any other cells in the human body, neurons are tasked with the unique problem of transporting important factors from sites of synthesis at the cell bodies, across enormous distances, along narrow-caliber projections, to distally located ...
Joseph A. White, Rupkatha Banerjee, Shermali Gunawardena   +2 more
doaj   +1 more source