Results 11 to 20 of about 395,686 (301)
Molecular motor proteins and amyotrophic lateral sclerosis. [PDF]
Int J Mol Sci, 2011 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis. Both inherited and sporadic forms of ALS share common pathological features, however, the initial trigger of neurodegeneration ...
Soo KY, Farg M, Atkin JD.
europepmc +4 more sources
A metal switch for controlling the activity of molecular motor proteins. [PDF]
Nat Struct Mol Biol, 2011 Kinesins are molecular motors that require a divalent metal ion (for example, Mg(2+)) to convert the energy of ATP hydrolysis into directed force production along microtubules. Here we present the crystal structure of a recombinant kinesin motor domain bound to Mn(2+) and ADP and report on a serine-to-cysteine substitution in the switch 1 motif of ...
Cochran JC, Zhao YC, Wilcox DE, Kull FJ.
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Synthetic, Protein-Based Molecular Motors [PDF]
Biophysical Journal, 2009 We present an approach that will lead to an understanding of the operational characteristics of biological molecular motors by designing and modeling synthetic molecular motors that use a combination of natural and designed biological components. One such design is a protein-based rotationally diffusive motor dubbed the Tumbleweed (TW).
Kuwada, Nathan J. +7 more
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Molecular switch-like regulation in motor proteins [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors that enhance or suppress their NTPase activity.
Sara Tafoya, Carlos Bustamante
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Chromatin maintenance by a molecular motor protein [PDF]
Nucleus, 2011 The kinesin motor protein KIF4 performs essential functions in mitosis. Like other mitotic kinesins, loss of KIF4 causes spindle defects, aneuploidy, genomic instability and ultimately tumor formation. However, KIF4 is unique among molecular motors in that it resides in the cell nucleus throughout interphase, suggesting a non-mitotic function as well ...
Manjari, Mazumdar +2 more
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Multiscale molecular dynamics simulations of rotary motor proteins [PDF]
Biophysical Reviews, 2017 Protein functions require specific structures frequently coupled with conformational changes. The scale of the structural dynamics of proteins spans from the atomic to the molecular level. Theoretically, all-atom molecular dynamics (MD) simulation is a powerful tool to investigate protein dynamics because the MD simulation is capable of capturing ...
Toru Ekimoto, Mitsunori Ikeguchi
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Frontiers in Molecular Biosciences, 2022 Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology.
Karthikeyan Selvarasu +7 more
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Novel LC8 Mutations Have Disparate Effects on the Assembly and Stability of Flagellar Complexes [PDF]
, 2009 LC8 functions as a dimer crucial for a variety of molecular motors and non-motor complexes. Emerging models, founded on structural studies, suggest that the LC8 dimer promotes the stability and refolding of dimeric target proteins in molecular complexes,
Davis, Stephanie +3 more
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Life without double-headed non-muscle myosin II motor proteins
Frontiers in Chemistry, 2014 Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC) belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has
Venkaiah eBetapudi
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A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, 2021 Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
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