Results 31 to 40 of about 395,686 (301)
Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease [PDF]
, 2017 Mitochondria fulfill a diverse range of functions in cells including oxygen metabolism, homeostasis of inorganic ions and execution of apoptosis. Biogenesis of mitochondria relies on protein import pathways that are ensured by dedicated multiprotein ...
MacPherson, Lisa +1 more
core +1 more source
Tumor Formation via Loss of a Molecular Motor Protein [PDF]
Current Biology, 2006 Aneuploidy has long been suggested to be causal in tumor formation. Direct testing of this hypothesis has been difficult because of the absence of methods to specifically induce aneuploidy. The chromosome-associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple mitotic defects including aneuploidy.
Mazumdar, Manjari +5 more
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Molecular Highways—Navigating Collisions of DNA Motor Proteins
Journal of Molecular Biology, 2018 Fundamental biological processes require concurrent sharing of DNA by numerous motor proteins and complexes. Thus, collision, congestion, and roadblocks are inescapable on these busy "molecular highways." The consequences of these traffic problems are diverse, resulting in complex cellular mechanisms to resolve threats to genome stability and ensure ...
Tung T, Le, Michelle D, Wang
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Theoretical Analysis of Dynamic Processes for Interacting Molecular Motors
, 2014 Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials.
Kolomeisky, Anatoly B. +2 more
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Localization of α-synuclein in teleost central nervous system: immunohistochemical and Western blot evidence by 3D5 monoclonal antibody in the common carp, Cyprinus carpio [PDF]
, 2015 Alpha synuclein (α-syn) is a 140 amino acid vertebrate-specific protein, highly expressed in the human nervous system and abnormally accumulated in Parkinson's disease and other neurodegenerative disorders, known as synucleinopathies.
CASINI, Arianna +6 more
core +1 more source
A physical model of cell metabolism [PDF]
, 2018 Cell metabolism is characterized by three fundamental energy demands: to sustain cell maintenance, to trigger aerobic fermentation and to achieve maximum metabolic rate.
Fernandez-de-Cossio-Diaz, Jorge +1 more
core +2 more sources
Transport of Molecular Motor Dimers in Burnt-Bridge Models
, 2007 Dynamics of molecular motor dimers, consisting of rigidly bound particles that move along two parallel lattices and interact with underlying molecular tracks, is investigated theoretically by analyzing discrete-state stochastic continuous-time burnt ...
Alexander Yu Morozov +5 more
core +1 more source
Motor proteins and molecular motors: how to operate machines at the nanoscale [PDF]
Journal of Physics: Condensed Matter, 2013 Several classes of biological molecules that transform chemical energy into mechanical work are known as motor proteins or molecular motors. These nanometer-sized machines operate in noisy stochastic isothermal environments, strongly supporting fundamental cellular processes such as the transfer of genetic information, transport, organization and ...
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An autonomous molecular transport system using DNAs and motor proteins in molecular communication [PDF]
2007 2nd Bio-Inspired Models of Network, Information and Computing Systems, 2007 This paper describes a molecular transport system in molecular communication that uses the machinery in living cells. The molecular transport system requires: 1) loading of the specified cargo molecules at a loading site (at a sender); 2) transport of the loaded cargoes to an unloading site (to a receiver); and 3) unloading of the transported cargoes ...
S. Hiyama +4 more
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Frontiers in Neuroscience, 2015 Pathological alterations of the Golgi apparatus, such as its fragmentation represent an early pre-clinical feature of many neurodegenerative diseases and have been widely studied in the motor neuron disease amyotrophic lateral sclerosis (ALS).
Georg eHaase, Catherine eRabouille
doaj +1 more source