Results 151 to 160 of about 3,104 (182)

Pigment Formation by <i>Monascus pilosus</i> DBM 4361 in Submerged Liquid Culture. [PDF]

J Agric Food Chem
Husakova M, Bezdicek M, Branska B, Sedlář K, Patakova P.   +4 more
europepmc   +1 more source

Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications. [PDF]

Biomedicines
Starvaggi J, Di Chio C, De Luca F, Previti S, Zappalà M, Ettari R.   +5 more
europepmc   +1 more source

Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study. [PDF]

Toxicol Res
Lee H, Do B, Kwon H.
europepmc   +1 more source

Red yeast rice extract improves lipid metabolism by modulating gut microbiota in high-fat diet mice. [PDF]

Front Pharmacol
Hu P, Zhang L, Hu H, Wang D, Chen J, Xiao J, Wu H, Qi L, Qin K, Zuo X, Li J.   +10 more
europepmc   +1 more source

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An overview of the bioactivity of monacolin K / lovastatin

Food and Chemical Toxicology, 2019
Monacolin K (MK) is the principal active substance in Monascus-fermentation products (e.g. red yeast rice). MK is effective in reducing cholesterol levels in humans and has been widely used as a lipid-lowering drug. The mechanism for this is through a high degree of competitive inhibition of the rate-limiting enzyme HMG-CoA reductase (HMGR) in the ...
Zhiwei Huang
exaly   +3 more sources

The effects of mutation and temperature variation on monacolin K production by monascus sp. and relative statistical parameter analysis of monacolin K production

Phytochemistry Letters, 2019
Abstract Monacolin K is a secondary metabolite of the Monascus species that restrains cholesterol synthesis. Temperature control is an effective method of improving the rate of monacolin K synthesis. Ultraviolet (UV) irradiation and ethylmethane sulfonate (EMS) were employed to mutate the Monascus strain so that it could be studied. After mutation by
Chung-Fu Huang, Wei-Ting Chen
exaly   +2 more sources

Effect of arginine supplementation on Monacolin K yield of Monascus purpureus

Journal of Food Composition and Analysis, 2022
Abstract Through a screening process, we previously revealed that the addition of arginine to Monascus fermentation broth significantly increased Monacolin K production, with 0.6% arginine showing the best effects. Herein, we added 0.6% arginine to further detect the effect of arginine on secondary metabolites and mycelium morphology of Monascus ...
Chan Zhang, Xuelian Yang, Baoguo Sun
exaly   +2 more sources

An overview on the biosynthesis and metabolic regulation of monacolin K/lovastatin

Food & Function, 2020
Lovastatin/monacolin K (MK) is used as a lipid lowering drug, due to its effective hypercholesterolemic properties, comparable to synthetic statins.
Yaru Zhang, Zhiting Chen, Qinyou Wen, Zixiao Xiong, Xiaohua Cao, Zhenghuai Zheng, Yangxin Zhang, Zhiwei Huang   +7 more
openaire   +2 more sources

Effects of glutamic acid on the production of monacolin K in four high-yield monacolin K strains in Monascus

Applied Microbiology and Biotechnology, 2019
Monascus purpureus is a traditional Chinese microbe that can be used as a medicinal herb and is edible. To improve the yield of monacolin K, we optimized the medium of M. purpureus with high-yield monacolin K strains. When high-yield strains C8, D8, E3, and I1 were grown in glutamic medium instead of the original medium, monacolin K production was ...
Chan Zhang, Shiyuan Chai, Shuai Hao, Anan Zhang, Qianqian Zhu, Han Zhang, Chengtao Wang   +6 more
openaire   +2 more sources

Total synthesis of (+)-monacolin K (mevinolin)

Tetrahedron Letters, 1983
Abstract (+)-Monacolin K (mevinolin) (1a), an extremely potent inhibitor of HMG-CoA reductase, has been stereospecifically synthesized from intermediate 2 employed in the synthesis of (+)-compactin (ML-236B) ( 1b ).
Masahiro Hirama, Mitsuko Iwashita
openaire   +1 more source