Results 101 to 110 of about 1,479 (165)

Synthesis of Monastrol and new Biginelli compounds promoted by In(OTf)

, 2005
Neste artigo, descrevemos uma rota prática para a síntese de compostos de Biginelli usando In(OTf)3. Para estudar a generalidade deste catalisador, vários exemplos usando aldeídos aromáticos, compostos 1,3-dicarbonil, uréia e tioureia foram investigados.
Kramer, Eliane, Godoi, Marla Narciso Biajoli, Costenaro, Hellen Sonego   +2 more
core   +1 more source

Elucidating binding mechanisms of pyrimidinone derivatives at the Eg5 kinesin active site: in silico drug discovery approach

Discover Chemistry
Cancer has emerged as a rapidly escalating global health challenge in the modern world. According to World Health Organization estimates from 2022, cancer affects approximately one in six individuals and remains a leading cause of mortality worldwide ...
Anandsing F. Patil, Kalpesh C. Sawant, Gaurav R. Gupta, Vijay S. Patil, Sharad R. Patil, Kiran R. Patil, Sandip P. Patil   +6 more
doaj   +1 more source

High-content Analysis in Monastrol Suppressor Screens

, 2011
SummaryObjectives: High-content screening (HCS) via automated fluorescent microscopy is a powerful technology for the effective expression of cellular processes.
Y. Ge, D. Zhang, Z. Zhang, X. Zhou
core   +1 more source

PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression [PDF]

Elife
Druker J, Jiang H, Shakir D, Child F, Alvarez V, Platani M, Corno A, Alabert C, Saurin A, Swedlow J, Rocha S, Lamond A.   +11 more
europepmc   +2 more sources

Anticonvulsant activity of aza-Biginelli derivatives related to JM-II-43A and HSAB-based rationalization of their pharmacological profile. [PDF]

J Comput Aided Mol Des
Ríos-Guerra H, Prada-Ramírez HA, Velasco-Bejarano B, López-Martínez M, Espinosa-Raya JE, Briones-Arandas A, Miranda-Ruvalcaba R, Nicolás-Vázquez MI, Gómez-Pliego R.   +8 more
europepmc   +1 more source

Benchtop ¹⁹F Nuclear Magnetic Resonance (NMR) Spectroscopy Provides Mechanistic Insight into the Biginelli Condensation toward the Chemical Synthesis of Novel Trifluorinated Dihydro- and Tetrahydropyrimidinones as Antiproliferative Agents. [PDF]

ACS Omega, 2023
Chen R, Singh P, Su S, Kocalar S, Wang X, Mandava N, Venkatesan S, Ferguson A, Rao A, Le E, Rojas C, Njoo E.   +11 more
europepmc   +1 more source

Development of Styryl-Modified 3,4-Dihydropyrimidin-2(1H)-ones as Potential Antitumor Agents. [PDF]

ChemMedChem
Panagoulias K, Kim W, Ozdemir M, Turan B, Mardinoglu A, Turkez H, Trisciuzzi D, Nicolotti O, Di Stefano A, Vassiliou S, Cacciatore I.   +10 more
europepmc   +1 more source

Synthesis and "in vitro" antineoplastic evaluation of goniothalamin-monastrol and piplartine-monastrol hybrids

, 2019
Orientador: Ronaldo Aloise PilliDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de QuímicaResumo: O câncer é uma das principais doenças que acometem a população mundial, sendo que no Brasil, estima-se um total de 600 mil novos casos
Grigolo, Thiago Augusto, 1993-
core  

Synthesis and <i>in vitro</i> antitumor evaluation of novel 3,4-dihydropyrimidinone-vorinostat hybrids against gastric and breast cancer cell lines. [PDF]

RSC Adv
Rios EAM, Pereira GMSDM, D'Oca MGM, Dea CM, Santos ERFB, Rampon DS, Santos LS, Nachtigall FM, Guzman L, Moore-Carrasco R, Rebolledo-Miraf D, D'Oca CRM.   +11 more
europepmc   +1 more source

Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting [PDF]

Nat Commun
Koprivec I, Štimac V, Đura M, Vukušić K, Mikec P, Tolić I.   +5 more
europepmc   +2 more sources