Results 81 to 90 of about 1,479 (165)

Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement

Cell Division, 2018
Background Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mammalian oocyte meiosis have not been
Yan Xie, Minghui Cheng, Shan Lu, Qilong Yuan, Dongyu Yang, Ying Chen, Chen Pan, Yurong Qiu, Bo Xiong   +8 more
doaj   +1 more source

KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?

BMC Cancer, 2009
Background Glioblastomas (GBM) are typically comprised of morphologically diverse cells. Despite current advances in therapy, including surgical resection followed by radiation and chemotherapy, the prognosis for patients with GBM remains poor ...
Ferruzzi Pietro, Rossi Marco, Kremer Andreas, Lamanna Claudia, Ghiron Chiara, Valensin Silvia, Nievo Marco, Bakker Annette   +7 more
doaj   +1 more source

Microtubule cytoskeleton and cell morphology, and cell-cycle distribution following 48h treatment with monastrol.

, 2015
(A) AGS and HT29 cells were treated for 48h with 100μM and 150μM of monastrol, respectively. Tubulin cytoskeleton was visualized following fixation by immunostaining, DNA was stained with DAPI.
Michal Hershfinkel (303795), Larisa Gheber (748552), Hila Asraf (748550), Rachel Avunie-Masala (748551)   +3 more
core   +1 more source

Methyl 6-methoxycarbonylmethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2008
The title compound, C15H16N2O5, belongs to the class of monastrol-type anti-cancer agents and was selected for crystal structure determination in order to determine the conformational details needed for subsequent structure–activity relationship ...
Lucia Veizerová, Jan Světlík, Viktor Kettmann   +2 more
doaj   +1 more source

Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.

, 2007
The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours.
Gartner, Michael, Giannis, Athanassios, Müller, Christine, Buschauer, Armin, Sarli, Vasiliki, Gross, Dietmar, Bernhardt, Günther   +6 more
core   +1 more source

A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens

Cell Reports, 2014
The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation.
Manuel Eguren, Mónica Álvarez-Fernández, Fernando García, Andrés J. López-Contreras, Kazuyuki Fujimitsu, Hiroko Yaguchi, José Luis Luque-García, Oscar Fernández-Capetillo, Javier Muñoz, Hiroyuki Yamano, Marcos Malumbres   +10 more
doaj   +1 more source

The Effect of Monastrol on the Processive Motility of a Dimeric Kinesin-5 Head/Kinesin-1 Stalk Chimera

, 2010
Controlled activity of several kinesin motors is required for the proper assembly of the mitotic spindle. Eg5, a homotetrameric bipolar kinesin-5 from Xenopus laevis, can cross-link and slide anti-parallel microtubules apart by a motility mechanism ...
Korneev, Mikhail J., Peterman, E.J.G., Schmidt, C.F., Korneev, M.J., Kapitein, Lukas C., Thiede, C., Reiter, S., Dueselder, Andre, Kapitein, L.C., Peterman, Erwin J. G., Lakamper, S., Lakaemper, Stefan, Thiede, Christina, Duselder, A., Schmidt, Christoph, Reiter, Stefanie   +15 more
core   +1 more source

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E., Khoudoli, Guennadi A., Swedlow, Jason R.; id_orcid, Andersen, Jens S., McAinsh, Andrew D., Andrew D. McAinsh, Swedlow, Jason R, Iain M. Porter, J. Julian Blow, Khoudoli, Guennadi A, Hunter, Christopher J., Blow, J. Julian; id_orcid, Guennadi A. Khoudoli, Jason R. Swedlow, Hunter, Christopher J, Sarah E. McClelland, Porter, Iain M, Porter, Iain M., Blow, J Julian, Andersen, Jens S; id_orcid, McClelland, Sarah E, Swedlow, Jason R., McAinsh, Andrew D, Blow, J. Julian, Jens S. Andersen, Christopher J. Hunter   +25 more
core   +1 more source

Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines

, 2018
An original and focused library of dihydropyrimidin-2-thiones N-1 aryl substituted derived from monastrol was designed and synthesized in order to discover a more effective Eg5 ligand.
Luciano Porto Kagami, Itamar Luís Gonçalves, Lauro Mera de Souza, Daniel Fábio Kawano, Gustavo Machado das Neves, Ivan da Rocha Pitta, Gabriela Göethel, Liliana Rockenbach, Gabriel Oliveira de Azambuja, Fabiana Nascimento, Amanda de Fraga Dias, Solange Cristina Garcia, Ana Maria Oliveira Battastini, Fabrício Figueiró, Daiana Silva Avila, Vera Lucia Eifler-Lima, Andressa Amaro   +16 more
core   +1 more source

Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations

Química Nova, 2014
A simple HPLC/UV method was developed for the determination of the anticancer candidate LaSOM 65 in rat plasma. Samples were cleaned by protein precipitation with acetonitrile (recovery > 95%), after which they were subjected to chromatography under the ...
Bruna G. S. Torres, Flávia D. T. Uchôa, Rômulo F. S. Canto, Allan Crestani, Vera Eifler-Lima, Teresa Dalla Costa   +5 more
doaj   +1 more source