Results 71 to 80 of about 1,479 (165)

Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. [PDF]

PLoS ONE, 2012
Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we
Line Groth-Pedersen, Sonja Aits, Elisabeth Corcelle-Termeau, Nikolaj H T Petersen, Jesper Nylandsted, Marja Jäättelä   +5 more
doaj   +1 more source

Efeito da adição de cadeias graxas ao monastrol em células de melanoma [PDF]

, 2015
O melanoma é o tipo de câncer da pele mais perigoso devido à formação de metástases. Essa neoplasia pode ser tratada por quimioterapia, radioterapia e cirurgia, entretanto, tratamentos alternativos estão sendo pesquisados.
Moraes, Milene Medeiros de
core  

Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes

Cell Division, 2020
Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She, Ning Zhong, Kai-Wei Yu, Yu Xiao, Ya-Lan Wei, Yang Lin, Yue-Ling Li, Ming-Hui Lu   +7 more
doaj   +1 more source

Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa

BMC Research Notes, 2009
Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne, Peters Nick T, Kropf Darryl L   +2 more
doaj   +1 more source

Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury

, 2015
While it is well established that the axons of adult neurons have a lower capacity for regrowth, some regeneration of certain CNS populations after spinal cord injury (SCI) is possible if their axons are provided with a permissive substrate, such as an ...
Klaw, Michelle C., Baas, Peter W., Tom, Veronica J., Xu, Chen, Lemay, Michel A.   +4 more
core   +1 more source

Combining synthetic and analytical strategies for preparative HPLC enantioseparation of monastrol racemic mixture

, 2004
Large-scale resolution of racemic monastrol has been carried out by normal-phase mode HPLC on an amylose-based chiral stationary phase. Because monastrol solubility, in media of proper compositions for normal-mode HPLC separations (in terms of retention ...
DONDI, Francesco, BRAGA S, CAVAZZINI, Alberto, BERGAMASCHI G, MASSI, Alessandro, DONDONI, Alessandro   +5 more
core   +1 more source

Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

Beilstein Journal of Organic Chemistry, 2009
A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable.
Mukund G. Kulkarni, Sanjay W. Chavhan, Mahadev P. Shinde, Dnyaneshwar D. Gaikwad, Ajit S. Borhade, Attrimuni P. Dhondge, Yunnus B. Shaikh, Vijay B. Ningdale, Mayur P. Desai, Deekshaputra R. Birhade   +9 more
doaj   +1 more source

Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathway [PDF]

Rearrangement of the actin cytoskeleton is a prerequisite for carcinoma cells to develop cellular protrusions, which are required for migration, invasion, and metastasis.
Pérez-Garrido, Alfonso, Bernabé-García, Ángel, Cayuela, María Luisa, Montoro-García, Silvia, Rodríguez-Martínez, Alejandro, Luchinat, Enrico, Postigo-Corrales, Fatima, Staderini, Tommaso, Bernabé-García, Manuel, Pérez-Sánchez, Horacio, Luque, Irene, Luengo-Gil, Ginés, Conesa-Zamora, Pablo, Alburquerque-González, Begoña, Salo, Tuula, Nicolás, Francisco José, Campioni-Rodrigues, Priscila   +16 more
core   +1 more source

Monastrol derivatives from lipophilic β-ketoesters by the Biginelli reaction [PDF]

, 2021
Las dihidropiridinas DHPMs son compuestos heterocíclicos de gran interés en la industria farmacológica por poseer múltiple actividad biológica en el tratamiento de diferentes enfermedades en especial contra el cáncer.
Aguilera Palacios, Edna Ximena
core  

CENP-W plays a role in maintaining bipolar spindle structure.

PLoS ONE, 2014
The CENP-W/T complex was previously reported to be required for mitosis. HeLa cells depleted of CENP-W displayed profound mitotic defects, with mitotic timing delay, disorganized prometaphases and multipolar spindles as major phenotypic consequences.
Agnieszka Kaczmarczyk, Kevin F Sullivan
doaj   +1 more source