Results 91 to 100 of about 1,479 (165)
Atividade anti-tumoral do composto LaSOM 65, derivado do monastrol, em linhagens de gliomas [PDF]
, 2011 Os gliomas são os tumores primários mais comuns no sistema nervoso central. Apesar dos progressos recentes no tratamento do glioblastoma, a sobrevida média dos pacientes ainda permanece em 15 meses.
Cristiane dos Santos Stuepp +1 more
core
, 2015 (A–D) AGS cells were stably transfected with a plasmid expressing GFP (vector) or a plasmid that encodes for overexpression of survivin-GFP (pSurvivin). Cells were treated with 100μM monastrol and processed for microtubule immunostaining (A and B), cell ...
Michal Hershfinkel (303795) +3 more
core +1 more source
, 2010 Objectives: Using the pteridine reductase (PTR1) enzyme of Leishmania as the target, the objective of our study was to find a drug candidate that can enter the clinical development process after being evaluated for safety and efficacy in animals. Methods:
Neeloo Singh +5 more
core +1 more source
Scientific Reports, 2017 A novel series of hybrid analogues of monastrol-1,3,5-triazine were designed and developed via one-pot synthesis using Bi(NO3)3 as a catalyst. Entire compounds were evaluated for their anticancer activity against HeLa (cervical cancer), MCF-7 (breast ...
Jitendra Kumar Srivastava +4 more
doaj +1 more source
Híbrido de monastrol-H2S : síntese e atividade antiproliferativa contra células de câncer de ovário
, 2015 Cancer represents one of the mayor causes of death in the world. According to OMS, this illness has been responsible for 8,2 million deaths in 2012, mainly due to the absence of efficient methods and drugs for treatment.
Taniris Cafiero Braga
core
The mitotic kinesin Eg5 is a motor protein involved in the formation of bipolar spindle and cell division. Eg5 is overexpressed in various cancer cells and Eg5 targeting agents are promising candidates for cancer therapy.
N. Razzaghi-Asl (18119229) +2 more
core +1 more source
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration
, 2007 Drugs that target mitotic spindle proteins have been proven useful for tackling tumor growth. Eg5, a kinesin-5 family member, represents a potential target, since its inhibition leads to prolonged mitotic arrest through the activation of the mitotic ...
DeBonis, S +6 more
core +1 more source
, 2014 γ-Hydroxybutyric acid (GHB) is a metabolite of γ-aminobutyric acid (GABA) and a proposed neurotransmitter in the mammalian brain. We recently identified α4βδ GABAA receptors as possible high-affinity GHB targets.
Higgins, David +6 more
core +1 more source