Results 51 to 60 of about 1,479 (165)
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.Chromosome bridge resolution during mitosis is influenced by the length of the bridging chromatin. Using CRISPR/Cas9, we engineered chromosome bridges with precisely defined intercentromeric distances. Results on the progression of these bridges during mitosis revealed that longer bridges require greater kinetochore separation to break than shorter ...
Teresa Anglada +3 more
wiley +1 more source
Sialic acid accelerates the electrophoretic velocity of injured dorsal root ganglion neurons
Neural Regeneration Research, 2015 Peripheral nerve injury has been shown to result in ectopic spontaneous discharges on soma and injured sites of sensory neurons, thereby inducing neuropathic pain.
Chen-xu Li +3 more
doaj +1 more source
Evidence that Monastrol Is an Allosteric Inhibitor of the Mitotic Kinesin Eg5
, 2002 Monastrol, a cell-permeable inhibitor of the kinesin Eg5, has been used to probe the dynamic organization of the mitotic spindle. The mechanism by which monastrol inhibits Eg5 function is unknown.
Maliga, Zoltan +2 more
core +1 more source
Neural Regeneration Research, 2015 The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet.
Eun Joo Bae +14 more
doaj +1 more source
CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC
Advanced Science, Volume 11, Issue 35, September 18, 2024.The spindle assembly checkpoint (SAC) maintains chromosome segregation fidelity by manipulating unattached kinetochore‐dependent mitotic checkpoint complex (MCC) assembly. CCDC68, an outer kinetochore protein, localizes to unattached kinetochores and interacts with CDC20 to inhibit its autoubiquitination and MCC disassembly.
Qi Li +6 more
wiley +1 more source
Neural Regeneration Research, 2015 In the aging brain, cognitive function gradually declines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used
Zhan-chi Zhang +5 more
doaj +1 more source
Neural Regeneration Research, 2015 Aging is the most prominent risk factor contributing to the development of neurodegenerative disorders. In the United States, over 35 million of elderly people suffer from age-related diseases.
Alessandro Castorina +3 more
doaj +1 more source
Cell Proliferation, Volume 57, Issue 5, May 2024.METTL16 catalyses the addition of m6A to Soga1 messenger RNA (mRNA) transcripts, leading to stabilization and increased levels of Soga1 mRNA through IGF2BP1‐mediated mechanisms. CDK1‐mediated phosphorylation of Soga1 generates a PLK1 docking site that promotes PLK1 activation.
Jimin Li +8 more
wiley +1 more source
ESTUDO PROSPECTIVO DO POTENCIAL ANTICÂNCER DO MONASTROL
, 2014 O estudo prospectivo tem como objetivo identificar o potencial antitumoral do monastrol, uma substância previamente usada como corante, e que a partir do ano 1999 vem demonstrando o seu potencial anticâncer.
Simões, Evelyne Rolim Braum +2 more
core +1 more source
, 2021 The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol - the first low molecular weight kinesin spindle ...
Reynisson, Jóhannes
core +1 more source