Results 41 to 50 of about 1,479 (165)
Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014
Neural Regeneration Research, 2015 Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research.
Guang-yao Liu +3 more
doaj +1 more source
Monastrol treatment rescues abnormal centriole splitting.
, 2014 (A) Representative panel of GFP-CENP-W cells transfected with siCENP-W for 48 h, incubated with monastrol (MON) for the last 4 h of transfection and stained for centrin-3 (centriole, red). The boxed enlargements show centriole pairs in control and siCENP-
Agnieszka Kaczmarczyk (217784) +1 more
core +1 more source
Neural Regeneration Research, 2015 Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen.
Jian-long Wang +6 more
doaj +1 more source
Neural Regeneration Research, 2015 With advances in biomedical methods, tissue-engineered materials have developed rapidly as an alternative to nerve autografts for the repair of peripheral nerve injuries. However, the materials selected for use in the repair of peripheral nerve injuries,
Yuan Gao +6 more
doaj +1 more source
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.
, 2018 The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled coil, and a C-terminal tail domain. In vivo HsEg5
Dimitrios A Skoufias (5065409) +11 more
core +1 more source
Hydrogen sulfide intervention in focal cerebral ischemia/reperfusion injury in rats
Neural Regeneration Research, 2015 The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion.
Xin-juan Li +6 more
doaj +1 more source
Small-Molecule and Mutational Analysis of Allosteric Eg5 Inhibition by Monastrol [PDF]
, 2006 Background: A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution.
Mitchison, Timothy +3 more
core +1 more source
Benchmarking Ploidy Estimation Methods for Bulk and Single‐Cell Whole Genome Sequencing
Advanced Science, Volume 12, Issue 45, December 4, 2025.It comprehensively benchmarks computational tools for ploidy estimation from bulk and single‐cell whole‐genome sequencing data. The results highlight the strengths and limitations of each method under different conditions and identify PURPLE and SeCNV show top performance in bulk and single‐cell settings, respectively.
Yawei Song +8 more
wiley +1 more source
, 2015 The synthesis and differential antiproliferative activity of monastrol (1a), oxo-monastrol (1b) and eight oxygenated derivatives 3a,b-6a,b on seven human cancer cell lines are described.
Canto, RFS +8 more
core +1 more source
, 2006 The treatment of malignant brain tumors poses a basic challenge in todays cancer therapy. Since the quantitative resection is hardly possible due to the invasive growth of the tumor, prevention of relapse after resection by concomitant irradiation ...
Gross, Dietmar
core +1 more source