Results 21 to 30 of about 1,479 (165)

Aufgabenspezifische Janus‐Materialien in der heterogenen Katalyse

Angewandte Chemie, Volume 134, Issue 39, September 26, 2022., 2022
Dieser Kurzaufsatz fasst die Fortschritte bei nano‐ und mikrostrukturierten Janus‐Materialien zusammen, einer neuen Generation heterogener Katalysatoren für chemische Reaktionen. Er adressiert Reduktionsreaktionen, oxidative Entschwefelung, Farbstoffabbau, asymmetrische Katalyse, Biomassetransformation, Kaskadenreaktionen, Oxidationsreaktionen ...
Majid Vafaeezadeh, Werner R. Thiel
wiley   +1 more source

Task‐Specific Janus Materials in Heterogeneous Catalysis

Angewandte Chemie International Edition, Volume 61, Issue 39, September 26, 2022., 2022
This Minireview summarizes recent advances in the application of nano‐ and microstructured Janus materials, which are a new generation of heterogeneous catalysts for various chemical reactions. Such materials can act as catalysts for reduction, oxidative desulfurization, dye degradation, asymmetric catalysis, biomass transformation, cascade reactions ...
Majid Vafaeezadeh, Werner R. Thiel
wiley   +1 more source

Spindle assembly trajectories with monastrol

, 2022
Morphological growth trajectories of meiotic spindle self-organization in Xenopus egg extracts supplemented with monastrol, a kinesin-5 ...
Yuta Shimamoto (13041201), Tatsuya Fukuyama (13127912)   +1 more
core   +1 more source

EHMT2-mediated R-loop formation promotes the malignant progression of prostate cancer via activating Aurora B. [PDF]

Clin Transl Med
Euchromatic histone lysine methyltransferase 2 (EHMT2) is overexpressed in advanced prostate cancer, restraining catastrophic chromosomal instability (CIN) and enhancing cell fitness. EHMT2 functions via the centromeric R‐loop‐driven ATR–CHK1–Aurora B pathway to promote chromosomal stability.
Zhang Y, Su M, Chen Y, Cui L, Xia W, Xu R, Xue D, Zhang X, Feng X.   +8 more
europepmc   +2 more sources

Age‐dependent aneuploidy in mammalian oocytes instigated at the second meiotic division

Aging Cell, Volume 21, Issue 7, July 2022., 2022
Ageing severely affects the chromosome segregation process in human oocytes resulting in aneuploidy, infertility and developmental disorders. We have studied the second meiotic division in oocytes from aged mice and established that post‐metaphase II processes have critical impact on age‐dependent aneuploidy in mammalian eggs.
Anna Kouznetsova, Jian Guo Liu, Sonata Valentiniene, Hjalmar Brismar, Christer Höög   +4 more
wiley   +1 more source

Novel cis‐Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action

Bioinorganic Chemistry and Applications, Volume 2022, Issue 1, 2022., 2022
One concept of improving anticancer effects of conventional platinum‐based antitumor drugs consists of conjugating these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, physicochemical characterization, biological effects, and mechanisms of action of four new analogs of ...
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec, Franc Perdih   +11 more
wiley   +1 more source

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B

Aging Cell, Volume 20, Issue 11, November 2021., 2021
AURKB in needed to preserve the female reproductive lifespan likely by protecting oocytes from oxidative stress. We show that Aurkb KO oocytes prematurely accumulate ROS during maternal aging. Prophase‐arrested oocytes from older females have reduced expression of SAC signaling components, causing a weakened SAC response during meiosis I.
Cecilia S. Blengini, Alexandra L. Nguyen, Mansour Aboelenain, Karen Schindler   +3 more
wiley   +1 more source

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5 [PDF]

, 2003
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled coil, and a C-terminal tail domain. In vivo HsEg5
DeBonis, S, Gans, Pierre, Simorre, Jean-Pierre, Ebel, Christine, Cross, Robert, Hackney, DD, Lebeau, Luc, Cross, R, Hackney, David, Blangy, A, Gans, P, Wade, RH, Ebel, C, Wade, Richard,, Crevel, Isabelle, Debonis, Salvatore, Skoufias, DA, Blangy, Anne, Wade, Richard, H., Crevel, I, Kozielski, F, Skoufias, Dimitrios, Kozielski, Frank, Lebeau, L, Simorre, JP   +24 more
core   +1 more source

Spindle assembly timelapse with monastrol

, 2022
Timelapse images of meiotic spindle self-organization in Xenopus egg extracts supplemented with monastrol (red: tubulin; green: DNA) 
Yuta Shimamoto (13041201), Tatsuya Fukuyama (13127912)   +1 more
core   +1 more source

Inhibitor library screening identifies ispinesib as a new potential chemotherapeutic agent for pancreatic cancers

Cancer Science, Volume 112, Issue 11, Page 4641-4654, November 2021., 2021
Ispinesib mediated anti–proliferative effects and significantly reduced the growth of Eg5‐positive pancreatic cancer in a patient‐derived xenograft mouse model. Moreover, Eg5‐positivity was associated with poorer clinical outcomes in pancreatic cancer patients.
Yoshiki Murase, Hiroaki Ono, Kosuke Ogawa, Risa Yoshioka, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe   +10 more
wiley   +1 more source