Results 11 to 20 of about 1,479 (165)

Kinesin-5 inhibitörü olan Monastrol bileşiğinin sentezi ve yük transferi kompleks etkileşmelerinin incelenmesi [PDF]

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2016
Kinesin-5 inhibitörü olarak kullanılan Monastrol, çözücüsüz ortamda alümina sülfonik asit (ASA) katalizörü varlığında 3-hidroksibenzaldehit, tiyoüre ve etilasetoasetat kullanılarak sentezlenmiştir.
Mustafa Arslan, Nurcan Berber
doaj   +3 more sources

Monastrol disrupts KIFC1-ATP dynamics: Towards newer anticancer mechanism

Chemical Physics Impact
Mitotic kinesins are eukaryotic proteins that play a vital role in cellular mitosis. Their over-expression in malignant rather than normal cells and their specific cellular role made kinesin inhibitors a promising cancer therapeutics.
Musab Ali, Ali H. Rabbad, Mahmoud E. Soliman   +2 more
doaj   +2 more sources

Catalyzed and non-catalyzed synthesis of bioactive monastrol [PDF]

Química Nova, 2014
The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions.
Haline G. O. Alvim, Jose R. Correa, Taynara R. Machado, Wender A. Silva, Brenno A. D. Neto   +4 more
doaj   +2 more sources

Monastrol derivatives: in silico and in vitro cytotoxicity assessments [PDF]

Research in Pharmaceutical Sciences, 2020
Background and purpose: Cancer is the leading cause of death in today’s world, therefore the efforts to achieve anticancer drugs with higher potency and fewer side effects have always been conducted by researchers in the field of pharmaceutical chemistry.
Zahra Bidram, Hajar Sirous, Ghadam Ali Khodarahmi, Farshid Hassanzadeh, Nasim Dana, Amir Ali Hariri, Mahboubeh Rostami   +6 more
doaj   +2 more sources

Síntese do monastrol e novos compostos de Biginelli promovida por In(OTf)3 Synthesis of monastrol and of new Biginelli compounds promoted by In(OTf)3

Química Nova, 2005
In this paper, we describe a practical route for the synthesis of Biginelli compounds using In(OTf)3. To study the generality of this catalyst, several examples using aromatic aldehydes, 1,3-dicarbonyl compounds, urea, and thiourea were investigated. The
Marla N. Godoi, Hellen S. Costenaro, Eliane Kramer, Paola S. Machado, Marcelo G. Montes D'Oca, Dennis Russowsky   +5 more
doaj   +2 more sources

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]

ChemSusChem
Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM, Scalzullo SM, Colacino E, Rivas ME.   +3 more
europepmc   +2 more sources

PB2382: EFFECTS OF ANTIFASCIN COMPOUNDS AGAINST LYMPHOMA CELLS IN VITRO [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S3, August 2023.
María Hurtado López A, Chedas D, José Sánchez de Las Matas Garre M, Postigo-Corrales F, Albaladejo González A, Beltrán Videla A, Torres-Moreno D, Belén Arroyo-Rodríguez A, García-Solano J, Conesa-Zamora P, Luengo-Gil G.   +10 more
europepmc   +2 more sources

Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles

Angewandte Chemie, Volume 135, Issue 21, May 15, 2023., 2023
Functional group‐controlled, RhIII‐catalyzed scaffold‐divergent synthesis of spirooxindole–isooxindoles and spirooxindole–oxindoles in combination with unbiased morphological bioactivity profiling reveal a unique Eg5 inhibitor chemotype. Abstract Oxindoles and iso‐oxindoles are natural product‐derived scaffolds that provide inspiration for the design ...
Jie Liu, Shubhadip Mallick, Yusheng Xie, Corentin Grassin, Belén Lucas, Beate Schölermann, Axel Pahl, Rebecca Scheel, Carsten Strohmann, Christoph Protzel, Thorsten Berg, Christian Merten, Slava Ziegler, Herbert Waldmann   +13 more
wiley   +2 more sources

Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells

Molecular Oncology, Volume 17, Issue 6, Page 1148-1166, June 2023., 2023
Tetraploidy arising through whole‐genome duplication is a cancer hallmark. Inhibitors of a mitotic kinesin CENP‐E preferentially suppress tetraploid cells over diploid counterparts with superior generality across different cellular backgrounds. Comparative imaging reveals tetraploidy‐linked aggravation of chromosome misalignment, mitotic delay ...
Koya Yoshizawa, Akira Matsura, Masaya Shimada, Sumire Ishida‐Ishihara, Fuyu Sato, Takahiro Yamamoto, Kan Yaguchi, Eiji Kawamoto, Taruho Kuroda, Kazuya Matsuo, Nobuyuki Tamaoki, Ryuichi Sakai, Yasuhito Shimada, Mithilesh Mishra, Ryota Uehara   +14 more
wiley   +1 more source

Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC

Advanced Science, Volume 10, Issue 10, April 5, 2023., 2023
FUS‐circTBC1D14‐associated stress granules (SGs) are transferred to the cytoplasm after being modified by PRMT1 and circTBC1D14 increases the stability of PRMT1 by inhibiting its K48‐regulated polyubiquitination. Then FUS‐circTBC1D14 can initiate a cascade of SGs‐linked proteins to control the elimination of SGs by recruiting LAMP1. The findings reveal
Ying Liu, Yiwei Liu, Yinqiao He, Ning Zhang, Siyue Zhang, Yaming Li, Xiaolong Wang, Yiran Liang, Xi Chen, Weijing Zhao, Bing Chen, Lijuan Wang, Dan Luo, Qifeng Yang   +13 more
wiley   +1 more source