Results 51 to 60 of about 13,855 (152)

The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors

Frontiers in Endocrinology, 2019
Testicular Germ Cell Tumors (TGCTs) are a rare group of neoplasms and the most common solid malignancy arising in young male adults. Despite the good response of these tumors to platinum-based chemotherapy, some patients are refractory to treatment and ...
Murilo Bonatelli, Eduardo C. A. Silva, Flavio M. Cárcano, Flavio M. Cárcano, Maurício G. Zaia, Luiz F. Lopes, Cristovam Scapulatempo-Neto, Cristovam Scapulatempo-Neto, Céline Pinheiro, Céline Pinheiro   +9 more
doaj   +1 more source

Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

Clinical and Translational Science, 2021
This study determined absolute transporter protein abundances in isolated microvessels of human noncancerous cerebral cortex as well as brain metastases of patients with lung and breast cancer, using a validated targeted proteomics approach.
Xun Bao, Jianmei Wu, Jun Jiang, An‐Chi Tien, Nader Sanai, Jing Li   +5 more
doaj   +1 more source

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu, Liang‐Liang Yao, Lin Jiang, Zhi‐Yi Fang, Jia‐Jun Zhu, Yi‐Sen Shao, Wen‐Juan Wang, Xiao‐Wen Wan   +7 more
wiley   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

Frontiers in Neuroscience, 2015
The transcriptome of embryonic and adult rat lateral ventricular choroid plexus, using a combination of RNA-Sequencing and microarray data, was analysed by functional groups of influx transporters, particularly solute carrier (SLC) transporters.
Norman Ruthven Saunders
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Molecular & Cellular Oncology, 2019
Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor.
Patrick D. Bosshart, David Kalbermatter, Sara Bonetti, Dimitrios Fotiadis   +3 more
doaj   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source

Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5

eLife, 2014
After endocytosis, membrane proteins can recycle to the cell membrane or be degraded in lysosomes. Cargo ubiquitylation favors their lysosomal targeting and can be regulated by external signals, but the mechanism is ill-defined. Here, we studied the post-
Michel Becuwe, Sébastien Léon
doaj   +1 more source