Results 71 to 80 of about 13,855 (152)
Physiological Reports, 2019 Growing evidence shows that lactate is not merely an intermediate metabolite, but also a potential signaling molecule. However, whether daily lactate administration induces physiological adaptations in skeletal muscle remains to be elucidated.
Kenya Takahashi +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade +13 more
wiley +1 more source
Mitochondrial physiology in cardiac muscle of deer mice native to high altitude
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia +7 more
wiley +1 more source
The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrupts Rat Lung Branching
Cellular Physiology and Biochemistry, 2013 Background/Aims: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate.
Sara Granja +7 more
doaj +1 more source
Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo +4 more
wiley +1 more source
A Glial Interplay Regulates Junctional Architecture at the Blood–Brain Barrier of Drosophila
Glia, Volume 75, Issue 1, January 2027.Drosophila perineurial glia are required for septate junction formation at the blood–brain barrier. Glucose transport across the blood–brain barrier is maintained in the absence of perineurial glia. Perineurial glia ablation increases glucose‐only diet sensitivity.
Esteban G. Contreras +7 more
wiley +1 more source
Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits
Glia, Volume 74, Issue 12, December 2026.To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom +11 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 21, 15 November 2026.Unacylated ghrelin (unAG) has been previously shown to acutely increase fatty acid oxidation (FAO) in skeletal muscle. 5 days of unAG administration to healthy male rats improved pyruvate tolerance, however this was not associated with changes in hepatic glucose‐production associated proteins.
Nicole M. Notaro +3 more
wiley +1 more source