Results 91 to 100 of about 13,009 (197)

Unveiling the Functional Role of KIF21B in Microglia Inflammatory Response

Glia, Volume 74, Issue 9, September 2026.
Microglia express KIF21B in both sexes. KIF21B binds to microglia cytoskeleton; inflammation alters such interaction promoting a phagocytic state in females. In male microglia KIF21B modulates migration. ABSTRACT Microglia are brain immune cells that maintain homeostasis and respond to injury, changing cell morphology to drive inflammation, migration ...
Danny Ganchala, Alvaro Bautista‐Abad, Daniel Pinto‐Benito, Julia Simon‐Areces, Daniela Grassi, Francesco Paolo Ulloa Severino, Maria‐Angeles Arevalo   +6 more
wiley   +1 more source

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, Volume 41, Issue 9, Page 709-729, September 2026.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

Focused Ultrasound‐Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri‐Focally Localized Glioblastoma Cells

International Journal of Cancer, Volume 159, Issue 4, Page 1005-1016, 15 August 2026.
Glioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Frieda Bayler, Jonna Holler, Jacqueline Clüver, Levi Johanning, Dana Hellmold, Nils Oliver Schröder, Jessica Nojszewski, Hajrullah Ahmeti, Carolin Kubelt‐Kwamin, Michael Synowitz, Janka Held‐Feindt   +10 more
wiley   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, Volume 11, Issue 4, Page 1095-1110, August 2026.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

MYC in Oncogenesis and Therapeutic Implications

MedComm, Volume 7, Issue 8, August 2026.
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang, Li Wei, Cuiping Tang, Peilong Lai, Wenbin Zhong, Hua You   +5 more
wiley   +1 more source

An experimental study on shrimp bioactive peptides restoring testicular function in a rat model of fatty liver disease via autophagy, redox balance, and energy transporters

International Journal of Reproductive BioMedicine
Background: Non-alcoholic fatty liver disease is a widely prevalent condition in the modern era, with potential adverse effects on fertility and the reproductive system.
Sahar Javanmard, Ebrahim Najdegerami, Mazdak Razi, Mehdi Nikoo   +3 more
doaj   +1 more source

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 826-838, August 2026.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source