Monomeric CRP regulates inflammatory responses in human intervertebral disc cells [PDF]
Bone & Joint Research, 2023 Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández +10 more
doaj +5 more sources
C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor [PDF]
Frontiers in Immunology, 2018 While leptin deficiency or dysfunction leads to morbid obesity, obese subjects are characterized paradoxically by hyperleptinemia indicating lack of response to leptin.
Manu Sudhakar +4 more
doaj +5 more sources
Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons [PDF]
Journal of Inflammation Research, 2021 Revathy Munuswamy,1,* Jana De Brandt,2,* Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,* Luc Michiels1,* 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium;
Munuswamy R +6 more
doaj +8 more sources
Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway [PDF]
Journal of Inflammation Research, 2021 Zhimin Zha,1,* Yujia Cheng,2,3,* Lu Cao,2 Yanxia Qian,2 Xinjian Liu,3,4 Yan Guo,1 Junhong Wang2 1Department of Gerontology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of ...
Zha Z +6 more
doaj +5 more sources
Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19. [PDF]
Front Immunol, 2023 The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Hopkins FR +12 more
europepmc +5 more sources
A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus [PDF]
Journal of Interdisciplinary Medicine, 2021 Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in the development of disease-related tissue damage.
Richter Patricia +5 more
doaj +5 more sources
Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein [PDF]
Frontiers in Immunology, 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an ...
Robert D. Williams +6 more
doaj +3 more sources
Beyond the Biomarker: Monomeric CRP as a Driver of Multisystem Pathology in Rheumatoid Arthritis. [PDF]
Int J Mol SciChronic inflammation underpins the pathogenesis of both rheumatoid arthritis (RA) and neurodegenerative conditions such as Alzheimer’s disease (AD). This narrative review explores the role of C-reactive protein (CRP), particularly its monomeric form (mCRP), as a central molecular link connecting systemic autoimmune inflammation with neuroinflammatory ...
Lazarut-Nistor A, Slevin M.
europepmc +3 more sources
Monomeric [CRP] and CRP-Controlled Stress and Pain Hypersensitization as Novel Predictors of Cognitive Disturbance and AD in Chronic Inflammatory Disease. [PDF]
Int J Mol SciChronic low-grade systemic inflammation is increasingly recognized as a key mediator linking stress, pain sensitivity, and cognitive decline. Central to this process are the acute-phase reactants interleukin-6 (IL-6) and C-reactive protein (CRP), which serve as biomarkers of systemic inflammation while promoting neuroimmune dysregulation.
Slevin M, Tero-Vescan A.
europepmc +2 more sources
C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]
Frontiers in ImmunologyC-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy +19 more
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