Results 11 to 20 of about 7,647 (170)

Increased C-reactive protein is associated with corneal nerve loss and painful neuropathic symptoms in Type 2 diabetes mellitus. [PDF]

J Diabetes Investig
Higher circulating C‐reactive protein, a marker of systemic inflammation, is associated with reduced corneal small nerve fiber density in individuals with Type 2 diabetes mellitus. Among participants with diabetic peripheral neuropathy, CRP levels are highest in those reporting positive neuropathic symptoms such as burning, painful cold, or electric ...
Ponirakis G, Al-Janahi I, Elgassim E, Petropoulos IN, Gad H, Khan A, Zaghloul HB, Ali H, Siddique MA, Abdulshakoor S, Concepcion JM, Khalfalla SH, Elamin ISA, AlZawqari ATH, Bibi T, El Deeb MA, Ahmed LHM, Dakroury Y, El Shewehy AMM, Salivon I, Minhas MQ, Ismail Y, Zirie MA, Al-Ansari Y, Al-Malaheem MAO, Quadros DJ, Atkin SL, Malik RA.   +27 more
europepmc   +2 more sources

Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator [PDF]

Frontiers in Immunology
Most early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Marc Potempa, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa, Lawrence A. Potempa   +4 more
doaj   +2 more sources

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]

Journal of Inflammation Research
Anniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C   +9 more
doaj   +2 more sources

An aptamer specifically targeting mCRP ameliorates experimental arthritis [PDF]

Journal of Orthopaedic Translation
Background: Recent evidence highlights the important role of the liver–bone axis in the development of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The liver secretes various factors that impact joint health, one of which is
Zhuqian Wang, Duoli Xie, Peixi Zhu, Jianmin Guo, Chunhao Cao, Yu Du, Aiping Lu, Chao Liang   +7 more
doaj   +2 more sources

Human Fcγ-receptors selectively respond to C-reactive protein isoforms [PDF]

Frontiers in Immunology
IntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ ...
Anna Henning, Johanna Seer, Johannes Zeller, Karlheinz Peter, Karlheinz Peter, Haizhang Chen, Julia Thomé, Philipp Kolb, Steffen U. Eisenhardt, Katja Hoffmann, Hartmut Hengel   +10 more
doaj   +2 more sources

C-reactive protein isoforms as prognostic markers of COVID-19 severity

Frontiers in Immunology, 2023
C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Blanca Molins, Marc Figueras-Roca, Marc Figueras-Roca, Oliver Valero, Víctor Llorenç, Víctor Llorenç, Sara Romero-Vázquez, Oriol Sibila, Alfredo Adán, Alfredo Adán, Carolina García-Vidal, Alex Soriano, Alex Soriano   +12 more
doaj   +1 more source

CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Frontiers in Immunology, 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt   +11 more
doaj   +1 more source

C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP [PDF]

Analytical and Bioanalytical Chemistry, 2011
Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric subunits of CRP (mCRP).
Min S, Wang, Joshua C, Black, Michelle K, Knowles, Scott M, Reed   +3 more
openaire   +2 more sources

C-reactive protein: a target for therapy to reduce inflammation

Frontiers in Immunology, 2023
C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single ...
Salma A. Rizo-Téllez, Salma A. Rizo-Téllez, Meriem Sekheri, Meriem Sekheri, János G. Filep, János G. Filep   +5 more
doaj   +1 more source

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
doaj   +1 more source