Results 21 to 30 of about 7,647 (170)

Association of monomeric C-Reactive Protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia.

European review for medical and pharmacological sciences, 2022
The ensuing ischemia due to the disruption of blood supply to the brain is one of the most common causes of stroke. Evidence suggests a clear association of the ischemic injury with vascular dementia and Alzheimer's disease (AD). In response to the brain ischemia, a cascade reaction starts leading to neuronal damage due to oxidative stress and other ...
Al-Baradie, RS, Abdel-Hadi, AM, Ahmad, F, Alsagaby, SA, Slevin, M, Alturaiki, W, Madkhali, Y, Aljarallah, BM, Alqahtani, M, Miraj, M, Ahmad, I, Albaradie, N, Albaradie, R   +12 more
openaire   +3 more sources

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants [PDF]

, 2017
Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the ...
Adán Civera, Alfredo, Antón, Rosa, Aróstegui Gorospe, Juan Ignacio, Dick, Andrew D., Fuentes Prior, Pablo, Molins Monteys, Blanca, Yagüe, Jordi   +6 more
core   +6 more sources

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Journal of Autoimmunity, 2023
The pentraxin C-reactive protein (CRP) is a pentameric protein now known to be able to undergo dissociation into a monomeric, modified isoform, referred to as mCRP. In carefully assessing the bioactivities of each isoform, mCRP has strong pro-inflammatory activities while pCRP has mild anti-inflammatory activities. Systemic lupus erythematosus (SLE) is
Jesper Karlsson, Jonas Wetterö, Lawrence A. Potempa, Rafael Fernandez-Botran, Yasmine O'Neill, Lina Wirestam, Fariborz Mobarrez, Christopher Sjöwall   +7 more
openaire   +4 more sources

Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection

Frontiers in Immunology, 2023
Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome.
Chengyang Liu, Chenyang Zheng, Xipeng Shen, Ling Liang, Qiuyu Li   +4 more
doaj   +1 more source

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

EMBO Molecular Medicine, 2022
C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert ...
Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt   +22 more
doaj   +1 more source

In vitro generation and bioactivity evaluation of C-reactive protein intermediate. [PDF]

PLoS ONE, 2018
The conformational conversion of pentameric C-reactive protein (pCRP) to monomeric CRP (mCRP) has been shown to play important roles in the action of CRP in inflammation regulation.
Jian-Min Lv, Ming-Yu Wang
doaj   +1 more source

Author Correction: Association of monomeric C-Reactive Protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia.

European review for medical and pharmacological sciences, 2023
Correction to: European Review for Medical and Pharmacological Sciences 2022; 26 (22): 8713-8718. DOI: 10.26355/eurrev_202212_30543- PMID: 36524490-published online on December 15, 2022. After publication, the authors applied a correction to the funding statement: The authors extend their appreciation to the deputyship for Research & Innovation ...
Al-Baradie, R.S., Abdel-Hadi, A., Ahmad, F., Alsagaby, S.A., Slevin, M., Alturaiki, W., Madkhali, Y., Aljarallah, B.M., Alqahtani, M., Miraj, M., Ahmad, I., Albaradie, N., Albaradie, R.   +12 more
openaire   +2 more sources

Factor H-Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation [PDF]

, 2015
The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense deposit
Banlaki, Z, Caesar, JJE, Csincsi, AI, Daigo, K, de Jorge, EG, Hamakubo, T, Hebecker, M, Jozsi, M, Kopp, A, Lea, SM, Pickering, MC, Uzonyi, B, Zoeldi, M   +12 more
core   +3 more sources

C-Reactive Protein in Atherosclerosis—More than a Biomarker, but not Just a Culprit

Reviews in Cardiovascular Medicine, 2023
C-reactive protein (CRP) is a pentraxin that is mainly synthesized in the liver in response to inflammatory cytokines. It exists in two functionally and structurally distinct isoforms.
Kürsat Kirkgöz
doaj   +1 more source

Extracellular vesicles are associated with C-reactive protein in sepsis

Scientific Reports, 2021
There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP (pCRP) into its structural isoform pCRP* and into monomeric CRP (mCRP).
Birgit Fendl, René Weiss, Tanja Eichhorn, Ingrid Linsberger, Taras Afonyushkin, Florian Puhm, Christoph J. Binder, Michael B. Fischer, Viktoria Weber   +8 more
doaj   +1 more source