Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents. [PDF]
PLoS ONEDue to the use of morphine as a well-known analgesic, a semi-synthesis of its newer triazole derivatives was performed in this project. Several derivatives were analyzed via molecular docking and a set of target molecules with acceptable docking scores ...
Faeze Nourmandipour +6 more
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Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue [PDF]
Pharmacology Research & Perspectives, 2023 The opioid epidemic has impacted over 10 million Americans in 2019. Opioids, like morphine, bind non‐selectively in both peripheral tissue, leading to effective pain relief, and central tissue, resulting in dangerous side effects and addiction.
Makena Augenstein +2 more
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Fluorescently Labeled Morphine Derivatives for Bioimaging Studies [PDF]
Journal of Medicinal Chemistry, 2018 Opioids, like morphine, are the mainstay analgesics for the treatment and control of pain. Despite this, they often exhibit severe side effects that limit dose; patients often become tolerant and dependent on these drugs, which remains a major health concern. The analgesic actions of opioids are primarily mediated via the μ-opioid receptor, a member of
Raymond Lam +6 more
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Pharmacology of Morphine and its Derivatives [PDF]
Proceedings of the Royal Society of Edinburgh, 1891 It is necessary for a clear understanding of the chemical changes which occur on treating morphine in various ways, and for comparing its physiological action with that of the bodies so formed, that we should summarise at some length the exact position of our present knowledge regarding its chemistry and pharmacology.Morphine has the composition ...
Ralph Stockman
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Morphine Derivatives with Antianalgesic Action [PDF]
Journal of Pharmacy and Pharmacology, 1954 Summary A series of N-alkyl substituted derivatives of morphine has been synthesised and examined for analgesic and antianalgesic action. Several of these compounds have shown powerful antianalgesic activity, N-propylnormorphine and the diacetyl and dipropionyl derivatives of N-allylnormorphine (nalorphine) being about as active as ...
A F Green, G K Ruffell, E Walton
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Медицинская иммунология, 2019 Anti-idiotypic antibodies (Ab2), according to the network theory of Jerne, are second-generation immunoglobulins that are produced against the idiotype of an antibody to a specific antigen.
A. V. Trofimov +9 more
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Effect of different doses of intrathecal morphine on postoperative fentanyl consumption in open live donor hepatectomy – A double-blind, randomized controlled trial [PDF]
Journal of Anaesthesiology Clinical PharmacologyBackground and Aims: Intrathecal morphine (ITM) has been widely used to provide effective postoperative analgesia. This study aims to compare the efficacy and safety of three different doses of ITM – 200, 300, and 400 μg – in patients undergoing open ...
Gaurav Sindwani +5 more
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Characterization of Opioid Agonist Morphine Derivatives with Emphasis on Medicinal Chemistry. [PDF]
ChemMedChemMalik A +7 more
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Genome Skimming Reveals Genetic Diversity in 220 Papaver Individuals from China [PDF]
Scientific DataAs a medicinal plant, Papaver holds significant value in the medical field. In China, the chemical synthesis of semi-derivatives such as morphine and codeine is limited, with the primary source being Papaver.
Fang Chen +8 more
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MORPHINE AND OTHER PHENANSHRENE DERIVATIVES [PDF]
The Journal of Nervous and Mental Disease, 1903 Jelliffe
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