Results 11 to 20 of about 10,950 (303)

Synthesis and Modification of Morphine and Codeine, Leading to Diverse Libraries with Improved Pain Relief Properties

Pharmaceutics, 2023
Morphine and codeine, two of the most common opioids, are widely used in the clinic for different types of pain. Morphine is one of the most potent agonists for the μ-opioid receptor, leading to the strongest analgesic effect.
Mona Kamelan Zargar Zarin, Wim Dehaen, Peyman Salehi, Amir Ata Bahmani Asl   +3 more
doaj   +1 more source

Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents

Research in Pharmaceutical Sciences, 2021
Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi, Maryam Mohammadi-Khanaposhtani, Faezeh Sadat Hosseini, Mahdi Gholami, Ahmad Reza Dehpour, Massoud Amanlou   +5 more
doaj   +1 more source

Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception [PDF]

, 2021
AbstractParental exposure to drugs of abuse such as opioids can have profound and long-lasting effects on reward processing and drug sensitivity across generations. However, little is known about the impact of long-term paternal exposure to morphine on offspring sensitivity to morphine-derived antinociception during painful experiences. To address this
Andre B. Toussaint, William Foster, Jessica M. Jones, Samuel Kaufmann, Meghan Wachira, Robert Hughes, Angela R. Bongiovanni, Sydney T. Famularo, Benjamin P. Dunham, Ryan Schwark, Nathan T. Fried, Mathieu E. Wimmer, Ishmail Abdus-Saboor   +12 more
openaire   +1 more source

Preparation of polyclonal and monoclonal anti-idiotypic antibodies against morphine-specific immunoglobulins

Медицинская иммунология, 2020
The preparation and study of anti-idiotypic (secondary) antibodies (Ab2) against monoclonal primary antibodies (Ab1) specific to biologically active molecules with a known structure is of great scientific and practical importance.
A. V. Trofimov, V. A. Atanesyan, A. M. Ischenko, E. A. Karabanova, A. Ya. Rak, A. S. Simbirtsev, N. B. Gamaleya, A. G. Berzina, N. V. Stankova, G. D. Kapanadze, L. I. Ulyanova, T. A. Klimova   +11 more
doaj   +1 more source

How μ-opioid receptor recognizes fentanyl

Nature Communications, 2021
Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear.
Quynh N. Vo, Paween Mahinthichaichan, Jana Shen, Christopher R. Ellis   +3 more
doaj   +1 more source

The Benzimidazole Derivatives, B1 (N-[(1H-Benzimidazol-2-yl)Methyl]-4-Methoxyaniline) and B8 (N-{4-[(1H-Benzimidazol-2-yl)Methoxy]Phenyl}Acetamide) Attenuate Morphine-Induced Paradoxical Pain in Mice

Frontiers in Neuroscience, 2019
Despite being routinely used for pain management, opioid use is limited due to adverse effects such as development of tolerance and paradoxical pain, including thermal hyperalgesia and mechanical allodynia.
Zahida Idris, Muzaffar Abbas, Humaira Nadeem, Arif-ullah Khan   +3 more
doaj   +1 more source

Prevalence, detection, symptoms of intoxication and treatment of new fentanyl analogue overdose with cyklopropylfentanyl (MAF) as an example

Alcoholism and Drug Addiction, 2022
The mortality rate attributable to new fentanyl analogue intoxication is a serious issue in various regions, especially in the U.S. In Poland, there have been poisonings reported since 2014 as regards these substances.
Sylwia Fudalej
doaj   +1 more source

Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. [PDF]

PLoS ONE, 2012
To enhance the drug-like properties of the endogenous opioid peptide endomorphin-1 (1 = Tyr-Pro-Trp-Phe-NH(2)), the N-terminus of the peptide was modified with 2-aminodecanoic acid, resulting in compound 3.
Pegah Varamini, Friederike M Mansfeld, Joanne T Blanchfield, Bruce D Wyse, Maree T Smith, Istvan Toth   +5 more
doaj   +1 more source

Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants

Molecules, 2020
Vaccination could be a promising alternative warfare against drug addiction and abuse. For this purpose, so-called haptens can be used. These molecules alone do not induce the activation of the immune system, this occurs only when they are attached to an
István Köteles, Károly Mazák, Gergő Tóth, Boglárka Tűz, Sándor Hosztafi   +4 more
doaj   +1 more source

Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice. [PDF]

PLoS ONE, 2016
Citrus Bergamia Risso, commonly known as Bergamot, is a fruit whose Essential Oil and Bergamot Polyphenolic Fraction have numerous medicinal properties.
Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino, Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli, Maurizio Muraca, Bianca M Goffredo, Vincenzo Mollace, Carolina Muscoli   +11 more
doaj   +1 more source