Results 21 to 30 of about 10,950 (303)

Pharmacological Studies on Morphine Derivatives. III

YAKUGAKU ZASSHI, 1964
Isao Seki, Hiromu Takagi, Shinsaku Kobayashi   +2 more
openalex   +3 more sources

High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors

Molecular Pain, 2009
Background Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic.
Messlinger Karl, Reeh Peter W, Forster Alexander B, Fischer Michael JM   +3 more
doaj   +1 more source

Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2-a]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action

Molecules, 2022
The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the final effect of analgesia.
Dominik Straszak, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Marcin Kołaczkowski, Aldona Pietrzak, Mansur Rahnama-Hezavah, Bartłomiej Drop, Dariusz Matosiuk   +8 more
doaj   +1 more source

Diels–Alder Adducts of Morphinan-6,8-Dienes and Their Transformations

Molecules, 2022
6,14-ethenomorphinans are semisynthetic opiate derivatives containing an ethylene bridge between positions 6 and 14 in ring-C of the morphine skeleton that imparts a rigid molecular structure.
János Marton, Anikó Fekete, Paul Cumming, Sándor Hosztafi, Pál Mikecz, Gjermund Henriksen   +5 more
doaj   +1 more source

Chronic paternal morphine exposure increases sensitivity to morphine-derived pain relief in male progeny [PDF]

Science Advances, 2022
Parental history of opioid exposure is seldom considered when prescribing opioids for pain relief. To explore whether parental opioid exposure may affect sensitivity to morphine in offspring, we developed a “rat pain scale” with high-speed imaging, machine learning, and mathematical modeling in a multigenerational model of paternal morphine self ...
Andre B. Toussaint, William Foster, Jessica M. Jones, Samuel Kaufmann, Meghan Wachira, Robert Hughes, Angela R. Bongiovanni, Sydney T. Famularo, Benjamin P. Dunham, Ryan Schwark, Reza Karbalaei, Carmen Dressler, Charlotte C. Bavley, Nathan T. Fried, Mathieu E. Wimmer, Ishmail Abdus-Saboor   +15 more
openaire   +2 more sources

Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest

ChemistryOpen, 2019
This review focuses on recent developments in the physicochemical profiling of morphine and other opioids. The acid‐base properties and lipophilicity of these compounds is discussed at the microscopic, species‐specific level.
Prof. Károly Mazák, Prof. Béla Noszál, Sándor Hosztafi   +2 more
doaj   +1 more source

Pharmacological investigations of N-substituent variation in morphine and oxymorphone: opioid receptor binding, signaling and antinociceptive activity.

PLoS ONE, 2014
Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain.
Tanila Ben Haddou, Szabolcs Béni, Sándor Hosztafi, Davide Malfacini, Girolamo Calo, Helmut Schmidhammer, Mariana Spetea   +6 more
doaj   +1 more source

Forensic Application of Genetic and Toxicological Analyses for the Identification and Characterization of the Opium Poppy (Papaver somniferum L.)

Biology, 2022
Background: A reliable and science-based taxonomic determination of Papaver somniferum L. (opium poppy), the illegal species of the genus Papaver, may have practical and legal implications for law enforcement. P.
Roberta Tittarelli, Angelo Gismondi, Gabriele Di Marco, Federico Mineo, Francesca Vernich, Carmelo Russo, Luigi Tonino Marsella, Antonella Canini   +7 more
doaj   +1 more source

Evaluation of Analgesic Activity of Newly Synthesized Phthalyl- tyrosyl-glycin Sodium

Iraqi Journal of Pharmaceutical Sciences, 2017
Alteration in the backbone structure of the endogenously released opioid peptides Leu5/Met5 enkephalins may result in compounds having comparable profile of pharmacological activity but with different physicochemical properties and side effects. Phthalyl
Muthanna S. AL-Taee, Kawkab Y. Saour, Haider M. Mohammed   +2 more
doaj   +3 more sources

Detection and accumulation of morphine in hair using GC–MS

Egyptian Journal of Forensic Sciences, 2016
Background: The detection of drugs ingested by humans by analyzing hair samples for their presence is now one of the imperative techniques in the field of forensic toxicology.
Himanshu Khajuria, Biswa Prakash Nayak
doaj   +1 more source