Results 31 to 40 of about 10,950 (303)

Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics

Frontiers in Medical Technology, 2021
Tyrosine-arginine (kyotorphin), an opioid analgesic dipeptide, was discovered more than 40 years ago in 1979. The evidence accumulated during this period has established the physiological significance of kyotorphin as a neuromodulating peptide, and ...
Hiroshi Ueda, Hiroshi Ueda, Hiroshi Ueda
doaj   +1 more source

A highly toxic morphine-3-glucuronide derivative

Bioorganic & Medicinal Chemistry Letters, 2004
By the coupling of octylamine to the uronic acid function of morphine-3-glucuronide (M3G) a new glycoconjugate (morphine-3-octylglucuronamide, M3GOAM) was prepared. When assayed in both rats and mice up to ng/kg (i.p.) doses none of the animals survived. The aliphatic octyl chain may be the lethal factor since a closely related derivative (M3GNH2), was
Salvatella, Mariona, Arsequell, Gemma, Valencia Parera, Gregorio, Rodríguez, Raquel E.   +3 more
openaire   +3 more sources

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon

Molecules, 2019
Here, we report a convenient synthetic procedure for the preparation of four novel indanyl carbanucleoside derivatives in the racemic form. The action of these compounds against hepatitis C virus was evaluated in vitro using the replicon cell line, Huh7 ...
Matías E. Gómez, Emiliano A. Gentile, M. Florencia Martini, María L. Cuestas, Verónica L. Mathet, Graciela Y. Moltrasio, Albertina G. Moglioni   +6 more
doaj   +1 more source

Krokodil—Morphine’s Deadly Derivative

Journal of Student Research, 2015
Graphically publicized in the media, the use of Krokodil, a heroin-like morphine derivative, has grown in Eastern Europe the last decade.  The popularity of the injectable drug has grown in part due to its inexpensive and simple manufacturing process through the use of codeine tablets.
openaire   +2 more sources

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor [PDF]

Neurotoxicity Research, 2017
Morphine has been shown to increase the expression of brain-derived neurotrophic factor (BDNF) in the brain. However, little is known about the effect of morphine withdrawal on BDNF and its precursor protein, or proBDNF, which induces neuronal apoptosis.
Alessia, Bachis, Lee A, Campbell, Kierra, Jenkins, Erin, Wenzel, Italo, Mocchetti   +4 more
openaire   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Unveiling the superior analgesic: Thoracic epidural versus intrathecal morphine in open live donor hepatectomy – A randomized controlled trial

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Postoperative pain management in open live donor hepatectomy is vital. This study aimed to compare postoperative analgesia provided by intrathecal morphine (ITM) and epidural in open live donor hepatectomy.
Rohit Saini, Gaurav Sindwani, Neha Garg, Mahesh K. Arora, Viniyendra Pamecha, Nihar Mohapatra   +5 more
doaj   +1 more source

Evaluation the Variation of Morphine Percentage in Different Turkish Opium Poppy (Papaver somniferum L.) Lines in Three Years [PDF]

Journal of Medicinal Plants and By-products, 2015
Opium poppy (Papaver somniferum L.) has two major products: alkaloids in the capsules and the seeds. It is known that opium poppy today contains alkaloid in great quantities.
Amir Rahimi, Neşet Arslan, Negar Valizadeh   +2 more
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