Synthetic compounds patterned after morphine alkaloids [PDF]
, 1940 Relationships between chemical constitution and pharmacological action of morphine, phenanthrene, dibenzofuran, and carbazole derivatives have been discussed;The preparations of some dibenzofuran derivatives, particularly those containing nitrogen, have ...
Cook, Thomas Henry
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Krokodil—Morphine’s Deadly Derivative
Journal of Student Research, 2015 Graphically publicized in the media, the use of Krokodil, a heroin-like morphine derivative, has grown in Eastern Europe the last decade. The popularity of the injectable drug has grown in part due to its inexpensive and simple manufacturing process through the use of codeine tablets.
openaire +3 more sources
Sulfate esters of morphine derivatives: Synthesis and characterization
European Journal of Pharmaceutical Sciences, 2011 Sixteen 3-O- and 6-O-sulfate esters of morphine, codeine and some of their N-methyl quaternary derivatives were synthesized by means of sulfation with pyridine-SO(3) complex and sulfuric acid/N,N'-dicyclohexylcarbodiimide. Complete (1)H- and (13)C-NMR assignments are given for each of the synthesized compounds based on one- and two-dimensional homo ...
Váradi, András +5 more
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Small-molecule CaVα1⋅CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking [PDF]
, 2018 Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the ...
Chen, Xingjuan +10 more
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Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]
, 2014 Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
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Opioid stimulation in the ventral tegmental area facilitates the onset of maternal behavior in rats [PDF]
, 1996 This research investigated the effect of an increase or decrease in opioid activity in the ventral tegmental area (VTA) on the onset of maternal behavior in rats.
Kristal, Mark B., Thompson, Alexis C.
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Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
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Detection of Drugs of Abuse by Raman Spectroscopy [PDF]
, 2011 Raman spectroscopy can provide rapid, sensitive, non-destructive analysis of a variety of drug types (e.g. amphetamines, alkaloids, designer drugs and date rape drugs). This review concentrates on developments in the past 15 years.
Ali +45 more
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Effect of Naloxone-3-Glucuronide and N -Methylnaloxone on the Motility of the Isolated Rat Colon After Morphine [PDF]
, 2018 The effect of the opioid antagonists naloxone-3-glucuronide and N-methylnaloxone on rat colon motility after morphine stimulation was measured. The rat model consisted of the isolated, vascularly perfused colon.
Batista, Catarina +5 more
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An index of fatal toxicity for new psychoactive substances [PDF]
, 2018 The final, definitive version of this paper has been published in Journal of Psychopharmacology, February 2018, published by SAGE Publishing, All rights reserved.An index of fatal toxicity for new psychoactive substances has been developed based solely ...
Corkery, John, King, L.A.
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