The gut microbiome contributes to somatic morphine withdrawal behavior and implicates a TLR2 mediated mechanism [PDF]
Gut Microbes, 2023 The ongoing opioid epidemic has left millions of people suffering from opioid use disorder due to the over-prescription of highly addictive substances.
Bridget Truitt +6 more
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AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal [PDF]
iScience, 2023 Summary: Dopamine D1 receptor-expressing medium spiny neurons (D1R-MSNs) and dopamine D2 receptor-expressing MSNs (D2R-MSNs) in nucleus accumbens (NAc) have been demonstrated to show different effects on reward and memory of abstinence.
Xiaohui Bai +10 more
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Linagliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor, Reduces Physical and Behavioral Effects of Morphine Withdrawal [PDF]
Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
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Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory [PDF]
iScienceSummary: The medial entorhinal cortex (MEC) is crucial for contextual memory, yet its role in context-induced retrieval of morphine withdrawal memory remains unclear. This study investigated the role of the MEC and its projection neurons from MEC layer 5
Yali Fu +16 more
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YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice [PDF]
BMC MedicineBackground Physical symptoms and aversion induced by opioid withdrawal strongly affect the management of opioid addiction. YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1), an m6A-binding protein, from the periaqueductal gray (PAG) reportedly ...
Chaopeng Ou +8 more
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Mitragynine Attenuates Morphine Withdrawal Effects in Rats—A Comparison With Methadone and Buprenorphine [PDF]
Frontiers in Psychiatry, 2020 BackgroundOpiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking.
Rahimah Hassan +6 more
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Morphine Withdrawal Enhances HIV Infection of Macrophages. [PDF]
Front Immunol, 2019 Opioid withdrawal recurs at high rates in opioid use disorder and compromises the immune system. In general, there are two types of opioid withdrawal: abrupt withdrawal (AW) and precipitated withdrawal (PW). In this study, we examined the effect of morphine AW or morphine PW on HIV infection of human blood monocyte-derived macrophages. We observed that
Wang X, Liu J, Zhou L, Ho WZ.
europepmc +5 more sources
Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]
Reviews in Clinical Medicine, 2015 Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar +5 more
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Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats [PDF]
Pharmaceutical Sciences Asia, 2022 Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia ...
Priscilla Kolibea Mante +7 more
doaj +1 more source
The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2023 Background and Aim: Serotonergic system has a role in morphine dependence and withdrawal symptoms via its receptors. On the other hand, the effect of 5-HT2A receptor on withdrawal symptoms has not been evaluated completely.
Nasrin Hashemi-Firouzi +4 more
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