Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal. [PDF]
PLoS ONE, 2012 Both the hypothalamus-pituitary-adrenal (HPA) axis and the extrahypothalamic brain stress system are key elements of the neural circuitry that regulates the negative states during abstinence from chronic drug exposure.
M Luisa Laorden +7 more
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Cell Reports, 2021 Summary: Previous work has shown that the paraventricular nucleus of the thalamus (PVT) is an important region that is involved in the conditioned context-induced retrieval of morphine withdrawal memory.
Lanfang Yu +9 more
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Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal. [PDF]
PLoS ONE, 2012 Experimental and clinical findings have shown that administration of adrenoceptor antagonists alleviated different aspects of drug withdrawal and dependence. The present study tested the hypothesis that changes in CREB activation and phosphorylated TORC1
Fátima Martín +5 more
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Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc). [PDF]
PLoS ONE, 2012 Stress induces the release of the peptide corticotropin-releasing factor (CRF) into the ventral tegmental area (VTA), and also increases dopamine (DA) levels in brain regions receiving dense VTA input.
Pilar Almela +6 more
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Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice
Substance Abuse: Research and Treatment, 2010 The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth +4 more
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Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice [PDF]
Brazilian Journal of BiologyRegarding the proven anticonvulsant effect of Zhumeria majdae essential oil (ZMEO) in previous studies we were prompted to investigate the ZMEO effects on the tolerance to the anticonvulsant effects of morphine and the morphine withdrawal syndrome ...
G. Azimi, J. Asgarpanah
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The effect of an incremental resistance training program on some apoptotic markers in the heart tissue of rats with morphine withdrawal syndrome [PDF]
مجله علوم پزشکی فیض (پیوسته), 2023 Background and Aim: The use of different drugs in withdrawal syndrome usually has little effectiveness and causes the person to become dependent on new substances.
Maryam Sadegh joola +2 more
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The (–)-Borneol Effect on Addiction/Abstinence by Morphine in Mice
Drugs and Drug Candidates, 2023 Opioids such as morphine are the first choice in acute and chronic pain treatment. However, they lead to addiction. Several studies have searched (i) to find a molecule that can replace morphine use or (ii) to reduce its adverse effects.
Maurício Pires de Moura do Amaral +8 more
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Flavonoids Reduce Morphine Withdrawal In-vitro
Journal of Pharmacy and Pharmacology, 1998 AbstractThe effects of quercetin, flavone, catechin and chrysin on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum have been investigated in-vitro.After 4 min in-vitro exposure to morphine a strong contracture of guinea-pig isolated ileum was observed after the addition of naloxone.
CAPASSO, Anna +3 more
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Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice
Journal of Biomedical Science, 2019 Background The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence in mice.
Faezeh Basiri +4 more
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