Results 61 to 70 of about 25,416 (201)

A human iPSC-derived midbrain neural stem cell model of prenatal opioid exposure and withdrawal: A proof of concept study.

PLoS ONE
A growing body of clinical literature has described neurodevelopmental delays in infants with chronic prenatal opioid exposure and withdrawal. Despite this, the mechanism of how opioids impact the developing brain remains unknown.
Rhea Sullivan, Quinn Ahrens, Sara L Mills-Huffnagle, Irina A Elcheva, Steven D Hicks   +4 more
doaj   +1 more source

Sensitization to morphine withdrawal in guinea-pigs

European Journal of Pharmacology, 2005
The aim of this study was to determine whether sensitization occurred to morphine withdrawal. Guinea-pigs were treated twice daily with increasing doses of morphine (10-100 mg/kg s.c.) for 3 days followed by injection of morphine 100 mg/kg on the fourth day.
Mizutani, Akiko, Arvidsson, J., Chahl, Loris Avril   +2 more
openaire   +3 more sources

Endoscopic‐Assisted Peri‐Root Anesthesia Provides Superior Intraoperative Analgesia Over Epidural Anesthesia in L5–S1 Interlaminar Endoscopic Discectomy

Orthopaedic Surgery, EarlyView.
The endoscopic‐assisted peri‐root anesthesia technique demonstrates superior intraoperative analgesic efficacy and a better safety profile compared to conventional epidural anesthesia in Delta large‐channel interlaminar endoscopic discectomy. This surgeon‐administered technique enhances patient comfort and procedural safety.
Hengrui Chang, Yuanqing Niu, Yiwen Zhang, Qi'ao Wu, Jiayuan Sun, Di Zhang, Jiaxin Xu   +6 more
wiley   +1 more source

Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala

BMC Biology, 2017
Background Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study of chronic morphine-induced adaptation in the brain and its functional significance is of importance to understand the mechanism of morphine ...
Yanfang Zhao, Junfang Zhang, Hualan Yang, Dongyang Cui, Jiaojiao Song, Qianqian Ma, Wenjie Luan, Bin Lai, Lan Ma, Ming Chen, Ping Zheng   +10 more
doaj   +1 more source

Cervical epidural catheter for administration of detomidine and morphine in a model of carpal synovitis in the horse

Veterinary Surgery, EarlyView.
Abstract Objective To determine the analgesic effects of detomidine and morphine administered by cervical epidural catheter (CEC) on a model of thoracic limb pain. Study design Prospective, randomized, blinded crossover study. Animals Five adult horses.
Veronica L. Edwards, Rachel Reed, Michael Perlini, Valerie J. Moorman   +3 more
wiley   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

The Effect of Nicotine Administration on Physical and Psychological Signs of Withdrawal Syndrome Induced by Single or Frequent Doses of Morphine in Rats

Basic and Clinical Neuroscience, 2012
Introduction. Morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. The present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and ...
Mohammad Allahtavakoli, Fatemeh Amin, Elham Hakimizadeh, Ali Roohbakhsh, Sayed Ali Haeri Rohani, Ahmad Taghavi Rafsanjani, Abbas Haghparast, Ali Shamsizadeh   +7 more
doaj   +2 more sources

Cultural Beliefs and Practices of Internationally Educated Nurses in the Context of Cancer and End‐Of‐Life Care: A Hermeneutic Inquiry

Journal of Advanced Nursing, Volume 82, Issue 4, Page 3509-3521, April 2026.
ABSTRACT Aims This study aimed to (1) gain an understanding of the experiences of IENs in providing cancer and end‐of‐life care; (2) explore their cultural beliefs and practices and analyse how their experiences, beliefs, and practices shape approaches to nursing care within this care context. Design Hermeneutic inquiry.
Jay Balante, Diane Van Den Broek, Kate White   +2 more
wiley   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 869-878, March 2026.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source