Results 1 to 10 of about 5,443 (141)

Monkeypox virus-infected individuals mount comparable humoral immune responses as Smallpox-vaccinated individuals [PDF]

Nature Communications, 2023
In early 2022, a cluster of monkeypox virus (MPXV) infection (mpox) cases were identified within the UK with no prior travel history to MPXV-endemic regions.
Ashley D. Otter, Scott Jones, Bethany Hicks, Daniel Bailey, Helen Callaby, Catherine Houlihan, Tommy Rampling, Nicola Claire Gordon, Hannah Selman, Panayampalli S. Satheshkumar, Michael Townsend, Ravi Mehta, Marcus Pond, Rachael Jones, Deborah Wright, Clarissa Oeser, Simon Tonge, Ezra Linley, Georgia Hemingway, Tom Coleman, Sebastian Millward, Aaron Lloyd, Inger Damon, Tim Brooks, Richard Vipond, Cathy Rowe, Bassam Hallis   +26 more
doaj   +2 more sources

Differentiating mpox infection and vaccination using a validated multiplex orthopoxvirus IgG serology assay [PDF]

Journal of Clinical Microbiology
The resurgence of monkeypox virus (MPXV) has increased demand for validated serological assays to assess exposure and immunity. Cross-reactivity among orthopoxviruses, stemming from high sequence conservation, complicates distinguishing antibody ...
Jonathan C. Reed, Cecilia Downs, Kaden McAllister, Clarice Mauer, Christopher L. McClurkan, Donna Wilson, Kate Holzhauer, Jane A. Dickerson, Chase A. Cannon, Tara M. Babu, Matthew R. Golden, David M. Koelle, Alexander L. Greninger   +12 more
doaj   +2 more sources

Antibodies Induced by Smallpox Vaccination after at Least 45 Years Cross-React with and In Vitro Neutralize Mpox Virus: A Role for Polyclonal B Cell Activation? [PDF]

Viruses
Aims: To evaluate whether antibodies specific for the vaccinia virus (VV) are still detectable after at least 45 years from immunization. To confirm that VV-specific antibodies are endowed with the capacity to neutralize Mpox virus (MPXV) in vitro.
Sabrina Mariotti, Giulietta Venturi, Maria Vincenza Chiantore, Raffaela Teloni, Riccardo De Santis, Antonello Amendola, Claudia Fortuna, Giulia Marsili, Giorgia Grilli, Maria Stella Lia, Seble Tekle Kiros, Filippo Lagi, Alessandro Bartoloni, Angelo Iacobino, Raffaele Cresta, Marco Lastilla, Roberto Biselli, Paola Di Bonito, Florigio Lista, Roberto Nisini   +19 more
doaj   +3 more sources

Rapid, sensitive, and highly specific detection of monkeypox virus by CRISPR-based diagnostic platform

Frontiers in Public Health, 2023
BackgroundMonkeypox (MPX), caused by the Monkeypox virus (MPXV), has incurred global attention since it broke out in many countries in recent times, which highlights the need for rapid and reliable diagnosis of MPXV infection.MethodsWe combined ...
Lin Gong, Xiaomin Chen, Yimei Wang, Jiansheng Liang, Xiaoli Liu, Yi Wang   +5 more
doaj   +1 more source

Monkeypox Virus Infection of Rhesus Macaques Induces Massive Expansion of Natural Killer Cells but Suppresses Natural Killer Cell Functions [PDF]

, 2013
Natural killer (NK) cells play critical roles in innate immunity and in bridging innate and adaptive immune responses against viral infection. However, the response of NK cells to monkeypox virus (MPXV) infection is not well characterized.
Blaney, Joseph E., Bollinger, Laura, Cohen, Melanie, Jahrling, Peter B., Janosko, Krisztina, Jennings, Gerald, Jett, Catherine, Johnson, Reed, Josleyn, Nicole, Reeves, R. Keith, Skinner, Jeff, Song, Haifeng   +11 more
core   +7 more sources

Development of multi-epitope vaccines against the monkeypox virus based on envelope proteins using immunoinformatics approaches

Frontiers in Immunology, 2023
BackgroundSince May 2022, cases of monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), have been increasingly reported worldwide. There are, however, no proven therapies or vaccines available for monkeypox.
Caixia Tan, Caixia Tan, Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Pinhua Pan, Pinhua Pan, Pinhua Pan, Pinhua Pan, Pinhua Pan, Anhua Wu, Anhua Wu, Chunhui Li, Chunhui Li   +15 more
doaj   +1 more source

Evaluation of the diagnostic performance of a commercial molecular assay for the screening of suspected monkeypox cases in Sri Lanka

Infectious Medicine, 2023
Background: The main objective of the present study was to compare the diagnostic performance of the commercial LightMix Modular Monkeypox Virus (MPXV) qPCR (TIB Molbiol, Germany) assay with the in-house nonvariola orthopox/monkeypox generic real-time ...
H.B.C. Harshani, G.A. Liyanage, D.V.R.G. Ruwan, U.K.I.U. Samaraweera, J.I. Abeynayake   +4 more
doaj   +1 more source

Determination of seroprevalence and kinetics of humoral response using mpox virus A29 protein

Communications Medicine, 2023
Background Mpox virus (MPXV), previously known as monkeypox virus, has spread globally in 2022. An accurate and convenient antibody test is essential for the determination of seroprevalence and for studying immune response after natural infection or ...
Jian-Piao Cai, Wing-Ming Chu, Anthony Raymond Tam, Kun Wang, Yuting Han, Lin-Lei Chen, Xiaojuan Zhang, Charlotte Yee-Ki Choi, Vincent Chi-Chung Cheng, Kwok-Hung Chan, Zhiwei Chen, Ivan Fan-Ngai Hung, Carol Ho-Yan Fong, Kelvin Kai-Wang To   +13 more
doaj   +1 more source

Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging. [PDF]

PLoS ONE, 2009
Monkeypox viruses (MPXV) cause human monkeypox, a zoonotic smallpox-like disease endemic to Africa, and are of worldwide public health and biodefense concern. Using viruses from the Congo (MPXV-2003-Congo-358) and West African (MPXV-2003-USA-044) clades,
Jorge E Osorio, Keith P Iams, Carol U Meteyer, Tonie E Rocke   +3 more
doaj   +1 more source

Evolutionary potential of the monkeypox genome arising from interactions with human APOBEC3 enzymes. [PDF]

, 2023
APOBEC3, an enzyme subfamily that plays a role in virus restriction by generating mutations at particular DNA motifs or mutational hotspots, can drive viral mutagenesis with host-specific preferential hotspot mutations contributing to pathogen variation.
Anthony, Simon, Davalos, Liliana, Delamonica, Brenda, Larijani, Mani, Liu, Jia, MacCarthy, Thomas   +5 more
core   +1 more source