Results 11 to 20 of about 5,325 (169)

Durability of the Humoral Response to MPXV Infection. [PDF]

J Int AIDS Soc
ABSTRACT Introduction Mpox virus (MPXV) re‐emerged in endemic countries in recent decades, resulting in large outbreaks in central and western Africa and a worldwide epidemic of clade IIb MPXV starting in 2022. Mpox cases in vaccinated persons, and a few documented reinfections, have raised questions about the durability of MPXV humoral immunity ...
Palmore TN.
europepmc   +3 more sources

Monkeypox virus (MPXV) neutralizing antibodies diagnosis with spectral-phase surface plasmon resonance 3D imaging biosensor

Journal of the European Optical Society-Rapid Publications
In this paper, we present the detection of Monkeypox virus (MPXV) neutralizing antibodies with a spectral-phase surface plasmon resonance (SPR) 3D imaging biosensor.
Wong Chi Lok
doaj   +2 more sources

One-Pot RPA-CRISPR/Cas12a Assay With Visual Readout for the Ultra-Specific Detection of Monkeypox Virus Clade I. [PDF]

Microb Biotechnol
This study established a rapid RPA‐CRISPR/Cas12a assay for MPXV clade I detection, achieving an LOD95 of 27.16 copies/μL within 40 min. The assay exhibited no cross‐reactivity with MPXV clade II or other orthopoxviruses. Under simulated conditions, the assay detected more low‐concentration plasmid‐spiked samples than quantitative polymerase chain ...
Li B, Liu L, Jin K, Huang Z, Zhang T, Gao R, Chen H, Niu L, Fan C, Zhang H, Huang P, Wang H.   +11 more
europepmc   +2 more sources

Clinically inapparent mpox virus (MPXV) infections among clients of three anonymous Community Based Voluntary Counselling and Testing centres in Berlin, Germany, 2022–2023 [PDF]

BMC Infectious Diseases
Introduction Since the mpox outbreak in 2022, it was unclear if and how often infections with mpox virus (MPXV) were clinically inapparent, i.e. not presenting to clinical care with mpox symptoms. Moreover, it was hypothesized that MPXV circulated in the
Uwe Koppe, Klaus Jansen, Axel Jeremias Schmidt, Christoph Weber, Heike Schulze, Robert Kasimir Kulis-Horn, Carsten Tiemann, Ulrich Marcus   +7 more
doaj   +2 more sources

Mpox Airborne Transmission: A Systematic Review. [PDF]

Rev Med Virol
ABSTRACT Since May 2022, mpox has been reported across multiple nonendemic regions, with concurrent outbreaks in diverse geographic settings, raising concerns about broader international spread. However, evidence regarding the risk of airborne transmission remains limited.
Theotonio Dos Santos LF, Arcuri LJ, Sant'Anna VAR, Couto PC, Schettino GPP, Rizzo LV, Fonseca HAR.   +6 more
europepmc   +2 more sources

CD4 Count and Clinical Outcomes of Mpox in People Living With HIV: A Systematic Review and Meta-Analysis. [PDF]

Health Sci Rep
ABSTRACT Background HIV causes immunosuppression by targeting CD4+ T lymphocytes, which may influence susceptibility and clinical outcomes of coinfections such as the Mpox virus (MPXV). Despite conflicting evidence, understanding the relationship between CD4 counts and MPXV severity in people living with HIV (PLWH) remains critical.
Batisani K, Chisompola D, Ogunniyi TJ, Wazhi GB, Simusokwe R, Chileshe M, Precious DU, Maenetja M, Mosweu R, Lubemba H, Ukaobasi SE, Mwangilwa N, Mulope L, Dine RD, Saleji C, Kazonga E, Onifade O, Agboola AO, Kwanga P, Zidana C, Chakulya M, Masenga SK.   +21 more
europepmc   +2 more sources

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein. [PDF]

MedComm (2020)
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Bai S, Song S, Wang X, Xiao Y, Long Y, Wu F, Wang F, Fan Z, Xu J, He M, Lu H.   +10 more
europepmc   +2 more sources

MpoxRadar: a worldwide MPXV genomic surveillance dashboard [PDF]

, 2023
The mpox virus (MPXV) is mutating at an exceptional rate for a DNA virus and its global spread is concerning, making genomic surveillance a necessity. With MpoxRadar, we provide an interactive dashboard to track virus variants on mutation level worldwide.
Kunaphas Kongkitimanon, Jorge Sánchez Cortés, Bernhard Y Renard, Kongkitimanon, Kunaphas, Brinkmann, Annika, Stephan Fuchs, Nitsche, Andreas, Schmachtenberg, Anna-Juliane, Andreas Nitsche, Anna-Juliane Schmachtenberg, Alice Wittig, Fuchs, Stephan, Wittig, Alice, Nasri, Ferdous, Cortés, Jorge Sánchez, Ferdous Nasri, Renard, Bernhard Y., Annika Brinkmann   +17 more
core   +1 more source

Monkeypox virus (MPXV)

, 2022
Monkeypox (MPXV) is a zoonosis with a double-origin DNA (DNA), caused by monkeypox virus, an orthopox virus and close relative of variola virus (smallpox).
Abdulkareem Salman Khudhair
core   +1 more source

MPXV DNA kinetics in bloodstream and other body fluids samples [PDF]

Since spring 2022, the global epidemiology of the monkeypox virus (MPXV) has changed. The unprecedented increase of human clade II MPXV cases worldwide heightened concerns about this emerging zoonotic disease.
Maria Beatrice Valli, Francesca Colavita, Daniele Focosi, Enrico Girardi, Fabrizio Maggi, Emanuele Nicastri, Tommaso Ascoli Bartoli, Annalisa Mondi, Maria Letizia Giancola, Giulia Matusali, David J. Sullivan, Claudia Minosse, Carmela Pinnetti, Valentina Mazzotta, Daniele Lapa, Klizia Mizzoni, Jiangda Ou, Silvia Meschi, Fabrizio Carletti, Andrea Antinori, Eliana Specchiarello   +20 more
core   +2 more sources