Results 11 to 20 of about 4,135 (173)

Durability of the Humoral Response to MPXV Infection. [PDF]

J Int AIDS Soc
ABSTRACT Introduction Mpox virus (MPXV) re‐emerged in endemic countries in recent decades, resulting in large outbreaks in central and western Africa and a worldwide epidemic of clade IIb MPXV starting in 2022.
Palmore TN.
europepmc   +5 more sources

Rapid, sensitive, and highly specific detection of monkeypox virus by CRISPR-based diagnostic platform

Frontiers in Public Health, 2023
BackgroundMonkeypox (MPX), caused by the Monkeypox virus (MPXV), has incurred global attention since it broke out in many countries in recent times, which highlights the need for rapid and reliable diagnosis of MPXV infection.MethodsWe combined ...
Lin Gong, Xiaomin Chen, Yimei Wang, Jiansheng Liang, Xiaoli Liu, Yi Wang   +5 more
doaj   +1 more source

One-Pot RPA-CRISPR/Cas12a Assay With Visual Readout for the Ultra-Specific Detection of Monkeypox Virus Clade I. [PDF]

Microb Biotechnol
This study established a rapid RPA‐CRISPR/Cas12a assay for MPXV clade I detection, achieving an LOD95 of 27.16 copies/μL within 40 min. The assay exhibited no cross‐reactivity with MPXV clade II or other orthopoxviruses. Under simulated conditions, the assay detected more low‐concentration plasmid‐spiked samples than quantitative polymerase chain ...
Li B, Liu L, Jin K, Huang Z, Zhang T, Gao R, Chen H, Niu L, Fan C, Zhang H, Huang P, Wang H.   +11 more
europepmc   +2 more sources

MpoxRadar: a worldwide MPXV genomic surveillance dashboard

Nucleic Acids Research, 2023
Abstract The mpox virus (MPXV) is mutating at an exceptional rate for a DNA virus and its global spread is concerning, making genomic surveillance a necessity. With MpoxRadar, we provide an interactive dashboard to track virus variants on mutation level worldwide.
Ferdous Nasri, Kunaphas Kongkitimanon, Alice Wittig, Jorge Sánchez Cortés, Annika Brinkmann, Andreas Nitsche, Anna-Juliane Schmachtenberg, Bernhard Y. Renard, Stephan Fuchs   +8 more
openaire   +4 more sources

Monkeypox virus-infected individuals mount comparable humoral immune responses as Smallpox-vaccinated individuals

Nature Communications, 2023
In early 2022, a cluster of monkeypox virus (MPXV) infection (mpox) cases were identified within the UK with no prior travel history to MPXV-endemic regions.
Ashley D. Otter, Scott Jones, Bethany Hicks, Daniel Bailey, Helen Callaby, Catherine Houlihan, Tommy Rampling, Nicola Claire Gordon, Hannah Selman, Panayampalli S. Satheshkumar, Michael Townsend, Ravi Mehta, Marcus Pond, Rachael Jones, Deborah Wright, Clarissa Oeser, Simon Tonge, Ezra Linley, Georgia Hemingway, Tom Coleman, Sebastian Millward, Aaron Lloyd, Inger Damon, Tim Brooks, Richard Vipond, Cathy Rowe, Bassam Hallis   +26 more
doaj   +1 more source

Determination of seroprevalence and kinetics of humoral response using mpox virus A29 protein

Communications Medicine, 2023
Background Mpox virus (MPXV), previously known as monkeypox virus, has spread globally in 2022. An accurate and convenient antibody test is essential for the determination of seroprevalence and for studying immune response after natural infection or ...
Jian-Piao Cai, Wing-Ming Chu, Anthony Raymond Tam, Kun Wang, Yuting Han, Lin-Lei Chen, Xiaojuan Zhang, Charlotte Yee-Ki Choi, Vincent Chi-Chung Cheng, Kwok-Hung Chan, Zhiwei Chen, Ivan Fan-Ngai Hung, Carol Ho-Yan Fong, Kelvin Kai-Wang To   +13 more
doaj   +1 more source

Development of multi-epitope vaccines against the monkeypox virus based on envelope proteins using immunoinformatics approaches

Frontiers in Immunology, 2023
BackgroundSince May 2022, cases of monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), have been increasingly reported worldwide. There are, however, no proven therapies or vaccines available for monkeypox.
Caixia Tan, Caixia Tan, Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Pinhua Pan, Pinhua Pan, Pinhua Pan, Pinhua Pan, Pinhua Pan, Anhua Wu, Anhua Wu, Chunhui Li, Chunhui Li   +15 more
doaj   +1 more source

Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging. [PDF]

PLoS ONE, 2009
Monkeypox viruses (MPXV) cause human monkeypox, a zoonotic smallpox-like disease endemic to Africa, and are of worldwide public health and biodefense concern. Using viruses from the Congo (MPXV-2003-Congo-358) and West African (MPXV-2003-USA-044) clades,
Jorge E Osorio, Keith P Iams, Carol U Meteyer, Tonie E Rocke   +3 more
doaj   +1 more source

Evaluation of the diagnostic performance of a commercial molecular assay for the screening of suspected monkeypox cases in Sri Lanka

Infectious Medicine, 2023
Background: The main objective of the present study was to compare the diagnostic performance of the commercial LightMix Modular Monkeypox Virus (MPXV) qPCR (TIB Molbiol, Germany) assay with the in-house nonvariola orthopox/monkeypox generic real-time ...
H.B.C. Harshani, G.A. Liyanage, D.V.R.G. Ruwan, U.K.I.U. Samaraweera, J.I. Abeynayake   +4 more
doaj   +1 more source

Mpox Airborne Transmission: A Systematic Review. [PDF]

Rev Med Virol
ABSTRACT Since May 2022, mpox has been reported across multiple nonendemic regions, with concurrent outbreaks in diverse geographic settings, raising concerns about broader international spread. However, evidence regarding the risk of airborne transmission remains limited.
Theotonio Dos Santos LF, Arcuri LJ, Sant'Anna VAR, Couto PC, Schettino GPP, Rizzo LV, Fonseca HAR.   +6 more
europepmc   +2 more sources