Results 11 to 20 of about 5,512 (205)

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science
The global outbreak of mpox caused by the mpox virus (MPXV) in 2022 and 2024 underscores the urgent need to elucidate mechanisms governing viral replication during pathogenesis. Metabolic reprogramming is a conserved hallmark of viral infections, however,
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
doaj   +2 more sources

Pathogenicity and contact transmissibility of clade IIb MPXV in African dormice

Emerging Microbes and Infections
The global outbreak of monkeypox virus (MPXV) in 2022 raised widespread scientific concern regarding potential changes in its biological characteristics.
Xiaohan Wang, Lina Liu, Manlin He, Shaowen Shi, Xiaoxuan Nie, Yongyang Sun, Wenhao Ren, Yuxing Wang, Yongzhe Zhang, Huanjie Han, Zhenjun Wang, Zirui Liu, Chao Shang, Qiwei Jiang, Zhendong Guo, Jianke Wang, Changbo Ou, Xiao Li, Zongzheng Zhao   +18 more
doaj   +3 more sources

MpoxRadar: a worldwide MPXV genomic surveillance dashboard

Nucleic Acids Research, 2023
Abstract The mpox virus (MPXV) is mutating at an exceptional rate for a DNA virus and its global spread is concerning, making genomic surveillance a necessity. With MpoxRadar, we provide an interactive dashboard to track virus variants on mutation level worldwide.
Ferdous Nasri, Kunaphas Kongkitimanon, Alice Wittig, Jorge Sánchez Cortés, Annika Brinkmann, Andreas Nitsche, Anna-Juliane Schmachtenberg, Bernhard Y Renard, Stephan Fuchs   +8 more
openaire   +3 more sources

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer-Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice. [PDF]

MedComm (2020)
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Tang C, Yuan L, Xie Y, Yang Y, Zhou Y, Wang J, Yang H, Peng R, Xu J, Yu W, Huang Q, Quan W, Li B, Wang Y, Lu S.   +14 more
europepmc   +2 more sources

Development of a specific MPXV antigen detection immunodiagnostic assay

Frontiers in Microbiology, 2023
Human monkeypox (mpox) has recently become a global public health emergency; however, assays that detect mpox infection are not widely available, largely due to cross-reactivity within the Orthopoxvirus genus. Immunoassay development was largely confined to researchers who focus on biothreats and endemic areas (Central and West Africa) until the 2022 ...
Ian Davis, Jackie M. Payne, Victoria L. Olguin, Madison P. Sanders, Tamara Clements, Christopher P. Stefan, Janice A. Williams, Jay W. Hooper, John W. Huggins, Eric M. Mucker, Keersten M. Ricks   +10 more
openaire   +3 more sources

GenomeBits Characterization of MPXV

Genes, 2022
Genome sequences of monkeypox virus (MPVX) causing the current outbreak are being reported from an increasing number of countries. We present a letter-to-numerical sequence study via GenomeBits signal mapping in order to characterize the evolution of the MPXV via simple statistical analysis. Histograms, empirical and theoretical cumulative distribution
openaire   +2 more sources

Monkeypox virus (MPXV)

World Journal of Advanced Research and Reviews, 2022
Monkeypox (MPXV) is a zoonosis with a double-origin DNA (DNA), caused by monkeypox virus, an orthopox virus and close relative of variola virus (smallpox). It was first reported in central Africa in 1970 and has historically affected some of the poorest and most marginalized communities in the world.
openaire   +1 more source

A Game-Theoretic Model of Monkeypox to Assess Vaccination Strategies [PDF]

, 2020
A Game-Theoretic Model of Monkeypox to Assess Vaccination Strategies Sri Vibhaav Bankaru, Depts. of Biomedical Engineering, Math, & Chemistry, Samuel Kossol, William Hou, & Parsa Mahmoudi, with Dr. Jan Rychtar, Dept.
Bankaru, Sri Vibhaav, Hou, William, Kossol, Samuel, Mahmoudi, Parsa, Rychtar, Jan   +4 more
core   +3 more sources

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics. [PDF]

MedComm (2020)
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yan Y, Sun Y, Sun G, Niu C, Zhao X, Zhao M, Liu T, Zhang S, Zhai H, Liu A, Yu S, Pan S, Zhong W, Zhang Y, Li S.   +14 more
europepmc   +2 more sources

Monkeypoxvirus (MPXV) in a Baby Monkey - Molecular Investigation

Acta Scientiae Veterinariae, 2023
Background: Monkeypox is a zoonotic virus that transmits from animal to human and human to human. Despite the fact that the Monkeypox virus (MPXV) was initially isolated in 1958 and the first human case was reported in 1970, thousands of cases have been documented in European countries, the United States, and Turkey in recent years.
Yakup Sinan Orta, Mehmet Kale, Özlem Özmen, Ayşegül Usta, Ozan Koçlu, Yakup Yıldırım   +5 more
openaire   +2 more sources